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Database: UniProt
Entry: H2LA72_ORYLA
LinkDB: H2LA72_ORYLA
Original site: H2LA72_ORYLA 
ID   H2LA72_ORYLA            Unreviewed;       461 AA.
AC   H2LA72;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   08-MAY-2019, entry version 43.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL2 (1 of many) {ECO:0000313|Ensembl:ENSORLP00000002777};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002777, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000002777}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002777};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000002777}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002777};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSORLP00000043986}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000043986};
RG   Ensembl;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   STRING; 8090.ENSORLP00000002777; -.
DR   Ensembl; ENSORLT00000002778; ENSORLP00000002777; ENSORLG00000002235.
DR   Ensembl; ENSORLT00000040298; ENSORLP00000043986; ENSORLG00000002235.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H2LA72; -.
DR   OMA; ECTALFP; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000001038; Chromosome 5.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    461       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018474350.
FT   ACT_SITE    138    138       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    358    358       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     50    341       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    214    230       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    366    377       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    371    424       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   461 AA;  52423 MW;  A24B7A75AAD3EBCF CRC64;
     MEGMVPAGQL LLTLFTSWIV ACAADTKQTN WPLYSQKPVL LVWNAPTQEC GTRHGVTLTL
     NQFDIVATPN EGFVRQNLTM FYKERLGLYP YFEHGGAAVH GGLPQLASLS QHYEKMPDSL
     QRYIPEPGAK GLAVIDWEEW RPLWIRNWDA KDIYRRKSCD LVAEKNLKWT PGEVEKVALQ
     EFELSARKFM VETLKLGKSL RPKQLWGFYL FPDCYNHNYK EGLRNYTGVC PAVEVERNNQ
     LNWLWMECTA FFPSIYMDSV LSSTNYGRLF VRNRVKEAMR LASVGDGLAR PVFVYTRPTY
     NGQMTLLTET DLVSTIGESV ALGAAGVIFW GDTSYASTTS CNILNKYLVG SLGRYLLNVS
     TAAEQCSKHL CRSLGRCFRR EPDRDVYLHL SSATHSITSP SGQLRVTGAP GKAELAFFRT
     HFQCQCYGFF CVFSSHRWRG RTCLFPQTVV LKKTKNKKKQ P
//
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