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Database: UniProt
Entry: H2LA77_ORYLA
LinkDB: H2LA77_ORYLA
Original site: H2LA77_ORYLA 
ID   H2LA77_ORYLA            Unreviewed;       570 AA.
AC   H2LA77;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Ras association domain-containing protein 1 {ECO:0000313|Ensembl:ENSORLP00000002783.2};
GN   Name=LOC101161547 {ECO:0000313|Ensembl:ENSORLP00000002783.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002783.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000002783.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002783.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000002783.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002783.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   RefSeq; XP_004068565.2; XM_004068517.2.
DR   AlphaFoldDB; H2LA77; -.
DR   STRING; 8090.ENSORLP00000002783; -.
DR   Ensembl; ENSORLT00000002784.2; ENSORLP00000002783.2; ENSORLG00000002241.2.
DR   GeneID; 101161547; -.
DR   KEGG; ola:101161547; -.
DR   CTD; 11186; -.
DR   eggNOG; KOG4239; Eukaryota.
DR   GeneTree; ENSGT00940000155664; -.
DR   HOGENOM; CLU_045544_0_0_1; -.
DR   InParanoid; H2LA77; -.
DR   OrthoDB; 4260488at2759; -.
DR   TreeFam; TF319243; -.
DR   Proteomes; UP000001038; Chromosome 5.
DR   Bgee; ENSORLG00000002241; Expressed in brain and 6 other cell types or tissues.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd20885; C1_RASSF1; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033614; RASSF1-6.
DR   InterPro; IPR011524; SARAH_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR22738:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR22738; RASSF; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF16517; Nore1-SARAH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50951; SARAH; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          278..328
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          423..517
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          519..566
FT                   /note="SARAH"
FT                   /evidence="ECO:0000259|PROSITE:PS50951"
SQ   SEQUENCE   570 AA;  64132 MW;  C60618F3AEF2BE64 CRC64;
     MISFISKLST TVYSHVSLEL LLFAINCSSS CRERLKTVSF CSNTRFFLFG IGERSLLFLQ
     DEGHMHALIM KTTLLLFMND SERGACAPRE AQTKNRTVAR VNVRRGESSS CAAAVTHEGI
     RSAVIPRSQC MRKPKCARLW RGCPPVIQRY PPKRLKTPAG LTSTRSLLLG LGSFVAEIHQ
     RCKGAAPALP SPLRAPHLSS HVKSNTSHVR VCTMSKCELI ELKDLSLNDP IELAAPSVHN
     TPPPVKSGQT SHHRVVRLVG DIVNIETSVH HPEEAALGHS FQPYSYTHLT WCDLCGEFIW
     GLYQKSLRCT NCSYTCHYRC QPFIQLKCSA PGSGSTETDT DDSIESDTNV DEQITIGLHD
     LTPAEIQQRV KEYNAQINNN LYMVDNKDGS FTGFIKVHFQ LVRPVSLPPL PQCQGLVQGE
     EQQGRCMKRR TSFYLPKDSA KHLHISSETR VREVIQALLN KFTVVDNPAK FALFERTEKQ
     SYVSMRKLSA DERPLHLRLC AGPSETLLCL VLKENDTGDV NWDAFSFPEL CNFLQILQRE
     EEEHVRQIVR RYTLAKERIK QAMAQINTPG
//
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