ID H2LA77_ORYLA Unreviewed; 570 AA.
AC H2LA77;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Ras association domain-containing protein 1 {ECO:0000313|Ensembl:ENSORLP00000002783.2};
GN Name=LOC101161547 {ECO:0000313|Ensembl:ENSORLP00000002783.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002783.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002783.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002783.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002783.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002783.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004068565.2; XM_004068517.2.
DR AlphaFoldDB; H2LA77; -.
DR STRING; 8090.ENSORLP00000002783; -.
DR Ensembl; ENSORLT00000002784.2; ENSORLP00000002783.2; ENSORLG00000002241.2.
DR GeneID; 101161547; -.
DR KEGG; ola:101161547; -.
DR CTD; 11186; -.
DR eggNOG; KOG4239; Eukaryota.
DR GeneTree; ENSGT00940000155664; -.
DR HOGENOM; CLU_045544_0_0_1; -.
DR InParanoid; H2LA77; -.
DR OrthoDB; 4260488at2759; -.
DR TreeFam; TF319243; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000002241; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd20885; C1_RASSF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 278..328
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 423..517
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 519..566
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
SQ SEQUENCE 570 AA; 64132 MW; C60618F3AEF2BE64 CRC64;
MISFISKLST TVYSHVSLEL LLFAINCSSS CRERLKTVSF CSNTRFFLFG IGERSLLFLQ
DEGHMHALIM KTTLLLFMND SERGACAPRE AQTKNRTVAR VNVRRGESSS CAAAVTHEGI
RSAVIPRSQC MRKPKCARLW RGCPPVIQRY PPKRLKTPAG LTSTRSLLLG LGSFVAEIHQ
RCKGAAPALP SPLRAPHLSS HVKSNTSHVR VCTMSKCELI ELKDLSLNDP IELAAPSVHN
TPPPVKSGQT SHHRVVRLVG DIVNIETSVH HPEEAALGHS FQPYSYTHLT WCDLCGEFIW
GLYQKSLRCT NCSYTCHYRC QPFIQLKCSA PGSGSTETDT DDSIESDTNV DEQITIGLHD
LTPAEIQQRV KEYNAQINNN LYMVDNKDGS FTGFIKVHFQ LVRPVSLPPL PQCQGLVQGE
EQQGRCMKRR TSFYLPKDSA KHLHISSETR VREVIQALLN KFTVVDNPAK FALFERTEKQ
SYVSMRKLSA DERPLHLRLC AGPSETLLCL VLKENDTGDV NWDAFSFPEL CNFLQILQRE
EEEHVRQIVR RYTLAKERIK QAMAQINTPG
//