ID H2LAG9_ORYLA Unreviewed; 650 AA.
AC H2LAG9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Eomesodermin homolog a {ECO:0000313|Ensembl:ENSORLP00000002878.2};
GN Name=eomesa {ECO:0000313|Ensembl:ENSORLP00000002878.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002878.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002878.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002878.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002878.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002878.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; H2LAG9; -.
DR STRING; 8090.ENSORLP00000002878; -.
DR Ensembl; ENSORLT00000002879.2; ENSORLP00000002878.2; ENSORLG00000002320.2.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158728; -.
DR HOGENOM; CLU_014430_8_1_1; -.
DR InParanoid; H2LAG9; -.
DR OrthoDB; 5323209at2759; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000002320; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IBA:GO_Central.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR GO; GO:0001714; P:endodermal cell fate specification; IBA:GO_Central.
DR GO; GO:0090504; P:epiboly; IEA:Ensembl.
DR GO; GO:0055109; P:invagination involved in gastrulation with mouth forming second; IEA:Ensembl.
DR GO; GO:0048382; P:mesendoderm development; IEA:Ensembl.
DR GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032385; T-box_assoc.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF13; EOMESODERMIN HOMOLOG; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF16176; T-box_assoc; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 211..396
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 18..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 71527 MW; 6267DBCF748B62AC CRC64;
MQLENILPSS SINLPKTFYN LSSTDSGNNS PRPSSQLDYQ EVERPESESR SAPKKFLGGV
GTGMLGEGEG DAFKADGRKG SPGLGEDELT SGRRYNIDEL GSDRYFISSS QASSDMANPC
SLFPYTGQTG SVYTGSGSSR YPASLHYGSV LPPAGFSSPS VCSGRSQFGS GGYQFSQGPG
CLYPSYPGTG AGIGSMSLPG SATGARAQVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL
SFNITGLNLT AHYNVFVEIV LADPNHWRFQ GGKWVTCGKA DNNMQGNKVY VHPESPNTGA
HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDMSNEARTQ
TFTFPENQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS MYTAPESDRL TPSPTDSPRS
TQIVPGARYA MQPFFQDQFV NNLPQNRFYT GERAVPQTNS LLSPQTEEAS AAASAQRWFV
PPVQQPCSNK LDLSYENDYS TSSLLSYGIK PLSLQTSHAL SYYPDSAFAS MAAGWGTRSS
YQRKMATGLP WSPRPSPPAF SEDQLGVTKD KLPEENLPPT STWIETSSSL KSLDSIDSGV
YSMVCKRRRM SPGGSSTENS PTIKCEDLTT EEYNKDNPKG MGYYAFYTSP
//
