ID H2LAI6_ORYLA Unreviewed; 1094 AA.
AC H2LAI6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=SH3 and PX domains 2A {ECO:0000313|Ensembl:ENSORLP00000002896.2};
GN Name=SH3PXD2A {ECO:0000313|Ensembl:ENSORLP00000002896.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002896.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002896.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002896.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002896.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002896.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LAI6; -.
DR Ensembl; ENSORLT00000002897.2; ENSORLP00000002896.2; ENSORLG00000002337.2.
DR GeneTree; ENSGT00940000157732; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000002337; Expressed in blastula and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR CDD; cd12074; SH3_Tks5_1; 1.
DR CDD; cd12077; SH3_Tks5_2; 1.
DR CDD; cd12019; SH3_Tks5_4; 1.
DR CDD; cd12020; SH3_Tks5_5; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035450; SH3PXD2A_SH3_1.
DR InterPro; IPR035452; SH3PXD2A_SH3_2.
DR InterPro; IPR035453; SH3PXD2A_SH3_4.
DR InterPro; IPR035454; SH3PXD2A_SH3_5.
DR PANTHER; PTHR15706:SF22; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00498; P47PHOX.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..77
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 109..168
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 209..268
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 396..455
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 774..833
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1033..1094
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 368..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 122203 MW; DF72550D369259B1 CRC64;
MQILDKFPIE GGQKDPKKRI IPFLPGKILF RRSHVRDVAM KRLRFIDDYC RALVRLPPLI
SQSEEVLRFF ETKPDDINPP VDGRSRRTVA GRWLTACFFP SGIDSSEPMV LEQYVAVANY
ERQENSEINL KAGETVDVIE KSESGWWFVS TAEEQGWVPA TYLESQSGTR DDSDLTTSRT
GEVTKRRKAH LKRLDRRWTL GGMVNRQQSR EEKYMTMQPY SSQGKDEVSF EKGVIVEVIQ
KNLEGWWYIR HQGKEGWAPA SYLKKVKEDF SRKKTLTGPV EIIGNIMEIS NLLQKKSVSE
KDIQTDSDGG ATPERHICKS EISLPMPFSA EINAETGRRL SAGRDTNSPC EPGSPAVARV
APHRVEIGSP NLRQKPPPRR DTNLGFQLPK PPEPPAVEAE YYTIADFQSS ISDGISFRGG
QKADVIEKNP GGWWYVQIGE MEGWAPCSYI DKRKKPNLSR RTSTLTRPKV PPPDPPIKKQ
EPDEAPLPPN TVSNAKDLAS KPVYEEPEYD VPAVGCEGEL DADFQKKERS QETKASHVIG
DKYHHSLPSS KASLPVCKAS PVFSHRRTSF RSVEDVAKGE CIYENDGFKQ SSSRTKVKGS
SEPNSPRSYH SSTVPRKPSG SSTLAGRPIK TMTPEMNQKS QTLGRQVNIS LRSQDSSPPS
SSDELGRDPK KSPVFSRDVE QRIGQSPSTR PKPSVRPKPL LTKSEPQSPE RMDIASLRRQ
LRPSSQYRRS LKPSRGDDSE TASVVSSTDS MTSRSTSDLS SVYSKGSCGD SDVEGPTLYR
SLDVYKKVQD SEISFPAGVE VEVLEKQESG WWYIRWGSEE GWAPSYYLEP VRPVGDSGVL
DSDEHGKIGG KSNSLEKNEQ HVQALNNINI QSLTQQNQCS RRNSPPIPSK PPGGFSKPSA
IINGGVRMRN GVRQVAVRPQ SVFVTTTQPA KDTHYMTGSL RRNESLGRSD YYGSGSATLG
VRRNASFSTV RPHVVVESQT RPSERSTLGS SGSNFSTNNV QDALSRVNQR NGIPVSTVRP
KPIERSQLIH NNLGKDVYVS IADYRGDEET MGFTEGTCLE VLERNPNGWW YCQVQDSLHP
RKGWVPSNYL ERKK
//
