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Database: UniProt
Entry: H2LAY4_ORYLA
LinkDB: H2LAY4_ORYLA
Original site: H2LAY4_ORYLA 
ID   H2LAY4_ORYLA            Unreviewed;       496 AA.
AC   H2LAY4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-OCT-2019, entry version 50.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000003050};
GN   Name=LOC101166987 {ECO:0000313|Ensembl:ENSORLP00000003050};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003050, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000003050, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003050,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000003050}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003050};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_004078725.1; XM_004078677.2.
DR   STRING; 8090.ENSORLP00000003050; -.
DR   Ensembl; ENSORLT00000003051; ENSORLP00000003050; ENSORLG00000002457.
DR   GeneID; 101166987; -.
DR   KEGG; ola:101166987; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193368; -.
DR   InParanoid; H2LAY4; -.
DR   KO; K05002; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000001038; Chromosome 17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR003276; K_chnl_inward-rec_Kir3.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF17; PTHR11767:SF17; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    142    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    220    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      106    245       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      252    419       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      448    496       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED       70     90       {ECO:0000256|SAM:Coils}.
FT   SITE        231    231       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   496 AA;  55519 MW;  AF165F481415C6DD CRC64;
     MALENSVFPS RPDSLALPVE EKEEGEAVEV ASASTGVFNL SEELGHVVTT ETTPSPPIKA
     KVNRSIQAKM ADQEAKANQH GKKIQAEKER GRFGWARARR KRQRYVEKNG RCNVQHGNMR
     KTYRYLTDIF TTLVDLNWRC SLFVFVMAYS VTWLFFGAIW YLIAYWRGDL DHLEDQTWTP
     CVNNVNGFIS AFLFSIETET TIGYGYRVIT DQCPVGTMLL LLQAILGSMV NAFMVGCMFV
     KISQPNKRAE TLVFSKHAVI SLRDDKLCLM FRVGDLRSSH IVGANMRAKL IKSKQTQEGE
     FIPLNQTDIS VGFETGDDRL FLVSPLVISH EIDSHSPFWD MSQAQLEKED FEIVVILEGM
     VEATGMTCQA RSSYLTEEVL WGHRFSPMML LAEGFFDIDY GAFHHTFEVD TPSCSARDLS
     LAAARLDAHL YWSISSRLDE EPTLASQATK QLDSSSANSK GGEATFTIGE MTDIQEQSGL
     GELNGSVATD QPESEA
//
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