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Database: UniProt
Entry: H2LBH2_ORYLA
LinkDB: H2LBH2_ORYLA
Original site: H2LBH2_ORYLA 
ID   H2LBH2_ORYLA            Unreviewed;       360 AA.
AC   H2LBH2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Ataxin-7-like protein 3 {ECO:0000256|HAMAP-Rule:MF_03047};
DE   AltName: Full=SAGA-associated factor 11 homolog {ECO:0000256|HAMAP-Rule:MF_03047};
GN   Name=ATXN7L3 {ECO:0000256|HAMAP-Rule:MF_03047};
GN   Synonyms=atxn7l3 {ECO:0000313|Ensembl:ENSORLP00000003245.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003245.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000003245.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003245.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000003245.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003245.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the transcription regulatory histone acetylation
CC       (HAT) complex SAGA, a multiprotein complex that activates transcription
CC       by remodeling chromatin and mediating histone acetylation and
CC       deubiquitination. Within the SAGA complex, participates in a subcomplex
CC       that specifically deubiquitinates histone H2B. The SAGA complex is
CC       recruited to specific gene promoters by activators, where it is
CC       required for transcription. {ECO:0000256|HAMAP-Rule:MF_03047}.
CC   -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT
CC       complexes. Within the SAGA complex, participates to a subcomplex of
CC       SAGA called the DUB module (deubiquitination module).
CC       {ECO:0000256|HAMAP-Rule:MF_03047}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03047}.
CC   -!- DOMAIN: The C-terminal SGF11-type zinc-finger domain forms part of the
CC       'catalytic lobe' of the SAGA deubiquitination module.
CC       {ECO:0000256|HAMAP-Rule:MF_03047}.
CC   -!- DOMAIN: The long N-terminal helix forms part of the 'assembly lobe' of
CC       the SAGA deubiquitination module. {ECO:0000256|HAMAP-Rule:MF_03047}.
CC   -!- SIMILARITY: Belongs to the SGF11 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03047}.
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DR   RefSeq; XP_004071299.1; XM_004071251.2.
DR   AlphaFoldDB; H2LBH2; -.
DR   Ensembl; ENSORLT00000003246.2; ENSORLP00000003245.2; ENSORLG00000002605.2.
DR   GeneID; 101170517; -.
DR   KEGG; ola:101170517; -.
DR   CTD; 368510; -.
DR   eggNOG; ENOG502QTTX; Eukaryota.
DR   GeneTree; ENSGT00940000167574; -.
DR   HOGENOM; CLU_066241_0_0_1; -.
DR   OrthoDB; 5404108at2759; -.
DR   TreeFam; TF324580; -.
DR   Proteomes; UP000001038; Chromosome 8.
DR   Bgee; ENSORLG00000002605; Expressed in testis and 14 other cell types or tissues.
DR   GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0000124; C:SAGA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.1270; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   HAMAP; MF_03047; Sgf11; 1.
DR   InterPro; IPR013246; SAGA_su_Sgf11.
DR   InterPro; IPR013243; SCA7_dom.
DR   PANTHER; PTHR46367; ATAXIN-7-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR46367:SF2; ATAXIN-7-LIKE PROTEIN 3; 1.
DR   Pfam; PF08209; Sgf11; 1.
DR   PROSITE; PS51505; SCA7; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|HAMAP-Rule:MF_03047};
KW   Chromatin regulator {ECO:0000256|HAMAP-Rule:MF_03047};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_03047};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_03047};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_03047};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_03047};
KW   Zinc-finger {ECO:0000256|HAMAP-Rule:MF_03047}.
FT   DOMAIN          199..266
FT                   /note="SCA7"
FT                   /evidence="ECO:0000259|PROSITE:PS51505"
FT   ZN_FING         84..105
FT                   /note="SGF11-type"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03047"
FT   REGION          116..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  39759 MW;  78368405DCC7B5A5 CRC64;
     MKMEDMPLSG PDNTKLEALV NDIYSELVED ACLGLCFEVH RAVKQGYFFL DETDQESMKE
     FEIVDQPGVD IFGQVYNQWK NKECECPNCK RLIAASRFAP HLEKCLGMGR NSSRIANRRL
     ASNNNTSKSE SDQEDNDDLN DNDWSYGAEK RAKKRKSDKS QNSPRRSKTL KHKNGELGSS
     MSADPYKYNY NAGINYEMLG PDEVRSFLTT QCGVISEHTK KMCTRSQRCP QHTDEQRMAV
     RVFLLGPSAP VLPEADSVAG PESFDIPDGQ ALMSRLQWED SPEISPSDSA SSKASTNHSD
     SRRPKKKKRP PLGLNSGGGI GSLSGGGGSG GSQTNISLST KKKKPKLTAP SISSIYDDLN
//
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