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Database: UniProt
Entry: H2LBV7_ORYLA
LinkDB: H2LBV7_ORYLA
Original site: H2LBV7_ORYLA 
ID   H2LBV7_ORYLA            Unreviewed;       417 AA.
AC   H2LBV7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   16-OCT-2019, entry version 56.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000003386};
GN   Name=kcnj10 {ECO:0000313|Ensembl:ENSORLP00000003386};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003386, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000003386, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003386,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000003386}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003386};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_004078624.1; XM_004078576.2.
DR   RefSeq; XP_011484308.1; XM_011486006.1.
DR   STRING; 8090.ENSORLP00000003386; -.
DR   Ensembl; ENSORLT00000003387; ENSORLP00000003386; ENSORLG00000002717.
DR   GeneID; 101162710; -.
DR   KEGG; ola:101162710; -.
DR   CTD; 3766; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186620; -.
DR   InParanoid; H2LBV7; -.
DR   KO; K05003; -.
DR   OMA; THEGRPC; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000001038; Chromosome 17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003269; K_chnl_inward-rec_Kir1.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF21; PTHR11767:SF21; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     86    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    190       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      197    363       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      396    417       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        176    176       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   417 AA;  46263 MW;  E01E04A037DCF72A CRC64;
     MTSATPPCSR SSSPHKVCHS QTQTDVLKPL LGGVLSGGSG TLRKRRRVLS KDGHSNVRIE
     HVRGRSALYM RDLWTTFLEM QWRYKFFLFT ATFAGTWFLF GVLWYLLALV HGDLLEFDPP
     SNHTPCVMQV QTLTGAFLFS LESQTTIGYG FRCITEECPI AIILLIVQLV ITMLMEIFIT
     GTFLAKVARP KKRGGTVKFS QHAVVSTLEG QPCLMIRVAN MRKSLLLGCQ VTGKLLQTSL
     TKEGETVRLD QRNVPFQVDT SSDSPFLILP LTFCHIIDDN SPLRAWAAKG GGWTDPELAD
     FELLVIMSAT VEPTSATCQV RTSYLPDEIL WGYEFPPVVS LSPSGKYVAD FSFFDKVAKT
     KTSPILTPSG LQSNGGGLVS EVLDPDKIRL EQSYREQRGE ERGRGRDGSL SVRVSNV
//
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