ID H2LCY0_ORYLA Unreviewed; 813 AA.
AC H2LCY0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Neural EGFL like 2 {ECO:0000313|Ensembl:ENSORLP00000003773.2};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSORLP00000003773.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003773.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003773.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003773.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003773.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003773.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_004069557.1; XM_004069509.2.
DR AlphaFoldDB; H2LCY0; -.
DR Ensembl; ENSORLT00000003774.2; ENSORLP00000003773.2; ENSORLG00000003018.2.
DR GeneID; 101157937; -.
DR KEGG; ola:101157937; -.
DR CTD; 4753; -.
DR GeneTree; ENSGT00810000125439; -.
DR OrthoDB; 5487at2759; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000003018; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..813
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172210"
FT DOMAIN 271..330
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 440..481
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 555..590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 602..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 638..693
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 698..756
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 525..535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 543..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 813 AA; 89778 MW; DD56EFA0C6F7B11B CRC64;
MGIFQLFLVL CIFFASSVVG FGVDPALRIS VFDELRLGDG FDGLTQVQGF HSETRAFHFQ
GSSREVRASA EVSAQMLKKL KGKNEFTVLA TVKQDRLNSG VILSVHQSDH RFLELESSGQ
RSEVRLHYRT KNQKDHTEVF PYSLADDQWH KISVAVSASH VILHVDCNRI YERVVEAPSM
DIPEDTSFWL GQRNAAHGFF KGVMQDVEVL VMPQGYISQC PDLNRTCPTC NDFHGLVQKI
MELQDILAKT SSKLSRAEEK MNGLDGCYCE RTCSVKGVIY REDEGWTDGC KNCTCTNGTV
HCEAISCPPP QCPAGTAPAY IKGACCKECQ PVCLFGGREL VEGDQRAVRD SSGRCLLFEC
RDRSMHRVVP SEPCPELSCP ESEQIALSNR CCKVCRGHDF CSEGHGCLEH SDCVNLEAGD
CCVCKDGFRP LRDDNAYCDD IDECAEGKHY CRENTMCVNT PGSFMCICHT GYIRIDDYSC
TEHDECLSGL HNCDENALCF NMVGGHSCSC KPGYTGNGTV CKAMCDGLCQ NGGTCVSPNK
CVCQQGFTGS RCETDIDECA DGFVECDSKS TCVNLPGWYH CECRDGYHDN GLFSANGESC
VDINECKTGR NTCANDTVCF NLEGGYDCRC PHGHNCTGDC IHDNKVKHSG QIWVLDNDRC
SVCSCQAGQV MCRRMVCDCD NPNADLFCCP ECDPRLSSQC LHQNGLLTYG SGDTWVENCQ
QCQCLQGQVD CWPLPCPPVD CEFTVVPEGE CCPRCVTDPC QADTIRNDIT KTCTDEHNIS
RFSGSSWIKH GTECTLCQCK NGHICCSVDP MCL
//
