ID H2LCY3_ORYLA Unreviewed; 824 AA.
AC H2LCY3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neural EGFL like 2 {ECO:0000313|Ensembl:ENSORLP00000003776.2};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSORLP00000003776.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003776.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003776.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003776.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003776.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003776.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H2LCY3; -.
DR STRING; 8090.ENSORLP00000003776; -.
DR Ensembl; ENSORLT00000003777.2; ENSORLP00000003776.2; ENSORLG00000003018.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00810000125439; -.
DR InParanoid; H2LCY3; -.
DR TreeFam; TF323325; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000003018; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..824
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017214286"
FT DOMAIN 271..330
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 440..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..511
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 513..548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 560..595
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 596..651
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 656..714
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 483..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 501..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 824 AA; 91074 MW; 240B11D043425229 CRC64;
MGIFQLFLVL CIFFASSVVG FGVDPALRIS VFDELRLGDG FDGLTQVQGF HSETRAFHFQ
GSSREVRASA EVSAQMLKKL KGKNEFTVLA TVKQDRLNSG VILSVHQSDH RFLELESSGQ
RSEVRLHYRT KNQKDHTEVF PYSLADDQWH KISVAVSASH VILHVDCNRI YERVVEAPSM
DIPEDTSFWL GQRNAAHGFF KGVMQDVEVL VMPQGYISQC PDLNRTCPTC NDFHGLVQKI
MELQDILAKT SSKLSRAEEK MNGLDGCYCE RTCSVKGVIY REDEGWTDGC KNCTCTNGTV
HCEAISCPPP QCPAGTAPAY IKGACCKECQ PVCLFGGREL VEGDQRAVRD SSGRCLLFEC
RDRSMHRVVP SEPCPELSCP ESEQIALSNR CCKVCRGHDF CSEGHGCLEH SDCVNLEAGD
CCVCKDGFRP LRDDNAYCDE HDECLSGLHN CDENALCFNM VGGHSCSCKP GYTGNGTVCK
AMCDGLCQNG GTCVSPNKCV CQQGFTGSRC ETDIDECADG FVECDSKSTC VNLPGWYHCE
CRDGYHDNGL FSANGESCVD INECKTGRNT CANDTVCFNL EGGYDCRCPH GHNCTGDCIH
DNKVKHSGQI WVLDNDRCSV CSCQAGQVMC RRMVCDCDNP NADLFCCPEC DPRLSSQCLH
QNGLLTYGSG DTWVENCQQC QCLQGQVDCW PLPCPPVDCE FTVVPEGECC PRCVTDPCQA
DTIRNDITKT CTDEHNISRF SGSSWIKHGT ECTLCQCKVS RHRQIPNCKL HLTSLSQRNP
FFFFAMKNPF QRKTKVVSLG LNICTLNGIS ASLQNDCSSA NTKR
//
