ID H2LD39_ORYLA Unreviewed; 544 AA.
AC H2LD39;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Islet cell autoantigen 1-like {ECO:0000313|Ensembl:ENSORLP00000003837.2};
GN Name=ical1 {ECO:0000313|Ensembl:ENSORLP00000003837.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000003837.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000003837.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003837.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000003837.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000003837.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004066704.1; XM_004066656.2.
DR AlphaFoldDB; H2LD39; -.
DR STRING; 8090.ENSORLP00000003837; -.
DR Ensembl; ENSORLT00000003838.2; ENSORLP00000003837.2; ENSORLG00000003074.2.
DR GeneID; 101168103; -.
DR KEGG; ola:101168103; -.
DR CTD; 378720; -.
DR eggNOG; KOG3891; Eukaryota.
DR GeneTree; ENSGT00390000005530; -.
DR HOGENOM; CLU_037158_1_0_1; -.
DR InParanoid; H2LD39; -.
DR OrthoDB; 5317533at2759; -.
DR TreeFam; TF317186; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000003074; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0051049; P:regulation of transport; IBA:GO_Central.
DR CDD; cd07661; BAR_ICA69; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR PANTHER; PTHR10164:SF5; ISLET CELL AUTOANTIGEN 1-LIKE PROTEIN; 1.
DR Pfam; PF06456; Arfaptin; 1.
DR Pfam; PF04629; ICA69; 1.
DR SMART; SM01015; Arfaptin; 1.
DR SMART; SM01237; ICA69; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS50870; AH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 51..254
FT /note="AH"
FT /evidence="ECO:0000259|PROSITE:PS50870"
FT REGION 281..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 60035 MW; FF6C4BD450E0B8D0 CRC64;
MDGFAGDLLS GGRALLGEDS SVMARMQKKF WKTKQVFIKV TGKKEDEYVV ASDADLDAKL
EFFRSVQSTC TELLKVIEKY QHRINRLSQE EKELGLFLRF QAEHDRTKAG KMMDATSKAL
CTSAKQRMAL CPPLQRMHQE VETFRRRAIA DTLLTVTRME KSRTEYRGAL LWMKDVSQEL
DPDTYKELEK FRKVQAQVRE TKSQFDKLKN DVCQKVDMLG ASRCNMLSHS LCTYQTTLLQ
FWEKTAHSLS GIHEAFLGHV PYQFSTIKEL RDPLEQISDL KNEEKKKKEE SSTDTLMCLD
EDKPAADADA GLSGVGRSQS SDAASADSTD DLMMLMALDM HHPQAPPPKK PPLLPQLLPP
CQTGGQSEHS NFGHPQLPVT GGGLLSGDPS FSSELAQKPE DEDSERSDMA FLKDLLSPDL
GSSDEFSREW QDAFGIFEPP ATPAVSAAAE VGPPSNPPCP SGFLPSQLLD QSLSSSGWVT
PPMFQAPPLQ PPMGQNQPAP QPVSSAASSG GSKDMSAWFN LFADLDPLSN PDAIGRSADE
LLNA
//
