ID H2LF48_ORYLA Unreviewed; 975 AA.
AC H2LF48;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Klotho {ECO:0000313|Ensembl:ENSORLP00000004579.2};
GN Name=KL {ECO:0000313|Ensembl:ENSORLP00000004579.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000004579.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000004579.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004579.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000004579.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004579.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004076338.1; XM_004076290.2.
DR AlphaFoldDB; H2LF48; -.
DR STRING; 8090.ENSORLP00000004579; -.
DR Ensembl; ENSORLT00000004580.2; ENSORLP00000004579.2; ENSORLG00000003675.2.
DR GeneID; 101168640; -.
DR KEGG; ola:101168640; -.
DR CTD; 9365; -.
DR eggNOG; KOG0626; Eukaryota.
DR GeneTree; ENSGT00940000157614; -.
DR HOGENOM; CLU_001859_5_2_1; -.
DR InParanoid; H2LF48; -.
DR OrthoDB; 3373839at2759; -.
DR TreeFam; TF314803; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000003675; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0040016; P:embryonic cleavage; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF10; KLOTHO; 1.
DR Pfam; PF00232; Glyco_hydro_1; 3.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..975
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017229689"
FT TRANSMEM 945..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 975 AA; 111584 MW; 3774EF7908228896 CRC64;
MLAFFIFLAV TPATGKPGDG LRTWGRFNRL PYPGDKAFLY DTFPKGFIWA VGTAAYPVEG
AFAKDGKGLS IWDTFTRGGT RKTCGDVGSD SYHNVDADIR AIQQLGVSHY RFSLSWPRMF
PNGTRGSYNE LGTNYYRTLI KRLKKINVQP VVTLYHWDLP EHLQQTLGGW ANPQLVDIFK
DYADFCFQTF GDDVKFWVTI DNPFVVAQHG YGTGVVAPGI KNDPDLRFRV GHNLLKAHAA
AWHIYDRHYR PRQQGKVSMA LASHWIKPSR TRLESLQECQ CSLDHVLGWF ARPLFTDGDY
PTCMKARLGS RLPSFTQEEK EWVKGTADFF ALSHGATLSF QLINDSVKFD QHEDLDLRML
LYWIYAEYDK PPIFVVQSGW YVLGNTKTKD PKQMFYLKSF IAETLKSIII DRVNVIGYTA
WSLIDGYEWY REYGIRRGLY YVSFNTPDMK REPKTSAIFY KNVIQKNGFP ELPENRPVQG
VFPCDFAWGV SANSVQVETT PTQFADPHVY LWNVSNNGEL IKLDGLIAPP LNRATHCADY
ASIRQQVDEI KQVGVSHFHF SLNWSAVVPT GDVANPNTTL LGYYRCFTRQ LLQANVTPVV
TLLHYTPKHS SLPAPLANTT NKWLSSEIPE AFANYARLCY RELGDYVKMW ITLNEPNDKE
VSYQEGHQML LAHARAWHVY DLEFRHSQGG QVSLVLHMNW VEPAFSFSRE DVEPAKRVLH
FTISWFAEPI FGSGDYPLEM RSWLRQLNSL ELPVFNEKDK KLVKGTYDFF AISHFSTDLV
THAKEDSYTY TARLEVQYMV DTTWIMSPRP VVPWGLRKAL NWVKEHYGDV PVYVMANGVQ
EDPSRFKDSL RVYYLYNYIN EALKAYILDG VNLKGYFVYA LNDQRDPKFG LYGQVHEEVI
VKASLPNYRN LIRHNGFPVQ GAAPQQCPAA PQACWGCHVL VKGPMVGFLT LVGSGVLITL
GLIIYYTSKR HKELY
//
