ID H2LFK6_ORYLA Unreviewed; 938 AA.
AC H2LFK6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Nucleotide binding oligomerization domain containing 1 {ECO:0000313|Ensembl:ENSORLP00000004745.2};
GN Name=NOD1 {ECO:0000313|Ensembl:ENSORLP00000004745.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000004745.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000004745.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004745.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000004745.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004745.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR RefSeq; XP_011483244.1; XM_011484942.1.
DR AlphaFoldDB; H2LFK6; -.
DR STRING; 8090.ENSORLP00000004745; -.
DR Ensembl; ENSORLT00000004746.2; ENSORLP00000004745.2; ENSORLG00000003812.2.
DR GeneID; 101170542; -.
DR KEGG; ola:101170542; -.
DR CTD; 10392; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000157845; -.
DR HOGENOM; CLU_011291_1_0_1; -.
DR InParanoid; H2LFK6; -.
DR OrthoDB; 3087860at2759; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000003812; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF18; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 11..76
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 184..324
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 938 AA; 105925 MW; 3153CA99D25E1FBE CRC64;
MEEASGPCLP LLTYHRELLV STLTSIQCLL DNLLLNGFFC QEDVEIVQRI PTKPDKVRKV
LELVQCKGEE ACEFFIYIIS KVCDAYRDLQ PWLEEINFHP RGSVIGMEVV NSDPISRYSQ
KLRYEISRDT SFIMSYGQQE ETQLEDLYTD TVMELLNDTN ENLGFLDNLD QLLGDDAVFN
PQGEVIYVMG DAGVGKSILL QKLANLWSKK ELKTDALFFF KFRCRMFNIF KDAEQISLRN
LLFKYNCYPD HDPDNEVFDY ILRFPEKVVF TFDGYDEIQE DVDIVKFPEV VSPEDKANAL
QLLMSLLSGK LLKGSKKVMT ARTGIEIQSR VLRKKVALRG FSPDHLKAYI DLHFKEQEHR
ELVSVQLDAS PHLCGLCSTP LFCWIVFKSF RHLQTMHDDF HLPDTCITLT NIFLLLCEVF
LSRLASPAAS SLRKGTRCTS ETFRAGLRPL TAFSRLALQG LERRSLICSQ EEISECGLTE
EDLALGFLKP VSDYDPGRGP GSFEFIHTTL QSFLAAFALV LEEQAPTGTI LKFFSECSWR
QEPSCLPFTF CIGRPVNLSL SKPFSTNEHF LFTNLFLCGL LAKSQLGLMG HLVCSNLLRK
KRATLKSYLS TVVRSHMKGL PTYKGDDGTK VHVLPNFLWM VRCIFETGSK QIAQMTAKGI
TPYFIKLGYC NVYSGDCTAL NFVLQHHRTL LRLDMDNNNI SDYGVKQLRP SFSRMTVVRL
SVNSLSDSSI EILAEELCKH KIVQILGLYN NNITDVGAKL VAHIIEECPK LAVLKLGKNK
ITGVGGRYLA LAIQKSTSIF DVGMWGNSIG DEGAEAFAKA LRNHPTLTNL SLAANGITSR
GGRILAEGLR ENSVLRIFWL VENKLGDDAA PTLAELVRAN TGLSHLWLIN NMLTVVGIRR
LAEALAVNTK FKEICVKGNQ ISKEEEKEFL LERRLRFH
//
