ID   H2LFX5_ORYLA            Unreviewed;       964 AA.
AC   H2LFX5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSORLP00000004867.2};
GN   Name=garnl3 {ECO:0000313|Ensembl:ENSORLP00000004867.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000004867.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000004867.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004867.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000004867.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004867.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2LFX5; -.
DR   Ensembl; ENSORLT00000004868.2; ENSORLP00000004867.2; ENSORLG00000003893.2.
DR   eggNOG; KOG3686; Eukaryota.
DR   GeneTree; ENSGT00940000159362; -.
DR   HOGENOM; CLU_008685_1_0_1; -.
DR   TreeFam; TF318626; -.
DR   Proteomes; UP000001038; Chromosome 12.
DR   Bgee; ENSORLG00000003893; Expressed in brain and 10 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00036; CNH; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT   DOMAIN          184..400
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          482..785
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          792..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..815
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        909..923
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   964 AA;  108315 MW;  9447A8B5C449AB67 CRC64;
     MSVTQAARVT MCFRYSSASE DLGCRRGDFS RKHYGSVELL ISSDADGAIQ RAGRFRVENG
     SSDETSPYTP GSWRRTDVHL ENPEYHTRWF FKYFLGKVHQ NYVGTDAEKN PFFLSVVLSD
     QNNQRVPQYR AILWRRSTLT GAICLSSNSP ISLVFSCSSY SAMNMDRFER GPREIMNPEI
     QKDLLVLEEQ EGSVNFKFGV LYAKDGQLTD DEMFSNEMGS ENFEKFLTLL GDTITLQGWA
     GYRGGLDTKN DTTGIKSIYT VYQGHELMFH VSTMLPYSKE NKQQVERKRH IGNDIVTIVF
     QEGDDTSSTF KPSMIRSHFT HIFALVKYNS QNDSYRLKIF SEESVPLFGP PLPSQPVFTD
     HQEFRDFLLV KLINGEKATL ETPTFAQKRQ RTLDMLIRSL YQDLTPDLHK NMLNRRSFSD
     VLPESPKSAR KKEEARQAEF VRIGQALKLK TIVRGDAPTS LVTTGLCRKE PWESQSFCST
     FPYEIVCADS WGQSLLVATD TAGVTQTLPP VPVFDKTMAV KQMHVLEPQD LLITRADKGK
     DARLYVFKLG TIKRSLEEKQ LIRGKCDCRE NKLEKTKGCH LYSINTHHGS ELRIVAAIRT
     KLLLITRKHP RFSAVASGAD SPVEEFQYIR EICLCDPPVV MALVDGPTGE NDNMICVAYK
     HQFDLINEST GDAYRLHHVD ANKVNFVAAI DVYEDGEAGL LLCYNYICHY KKVCPFNGST
     PMMQSNTPDF HFSWNQMPNA IVCAFPYILA FTTDSIEIRL VVNGNLVYTA VVPELQLAAS
     RSDIYFVSSA PVSSASNCSS RDTSSQSSPQ TPTGYEMPVF PSPLGDGEVT CKHIFKIPLC
     NLVGRSIERP LKSPLVNKVL TAPTPAMAPP TPLISATHSL SLSRMEIKEI ASRTRKELLG
     RKGNHHNPFR PTSESSGADS DVQLHCPSSL DAEPEKALLQ EECPPLTDVF TLPSTFEEDV
     LDLK
//