ID H2LG92_ORYLA Unreviewed; 745 AA.
AC H2LG92;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB8 {ECO:0000313|Ensembl:ENSORLP00000004985.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000004985.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000004985.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004985.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000004985.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000004985.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_011479118.1; XM_011480816.1.
DR AlphaFoldDB; H2LG92; -.
DR STRING; 8090.ENSORLP00000004985; -.
DR Ensembl; ENSORLT00000004986.2; ENSORLP00000004985.2; ENSORLG00000003989.2.
DR GeneID; 101167379; -.
DR KEGG; ola:101167379; -.
DR CTD; 3696; -.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_3_1_1; -.
DR InParanoid; H2LG92; -.
DR OrthoDB; 5475862at2759; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000003989; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF9; INTEGRIN BETA-8; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..745
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017399691"
FT TRANSMEM 661..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..82
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 41..459
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DISULFID 34..459
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 42..52
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 45..81
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 55..70
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 196..203
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 251..292
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 396..407
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 457..461
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 515..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 520..533
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 554..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 561..570
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 572..579
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 592..597
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 599..609
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 745 AA; 81852 MW; 7AE1D2455E40813C CRC64;
MTSWLRSYGS VPLCVLLACM VWCAEASSTG ASVCWSPSVT SCSDCLRRGP QCAWCFKEDF
LDKVGPSHRC DLPGNLQKRG CGPEFLELSE IKVEVGRLTR TQVSPQHISI TLRPGSEASF
IVAVTQLERY PVDLYYLVDV SASMQENLDH LKTVGVALSL RMMQHTSDLW LGFGSFVDKP
VSPYINVHPS KINNPCSDYE IRCRPAHGFH HVLSMTGNMS EFTRTIKRQR ISGNMDTPEG
GLDAMLQAAV CQDAVGWRSE AKRLLLLMTD QPSHLALDSR LAGIVVPHDG LCHLENNVYT
GSTKMDHPSL GQLSEKLLEN HIYSVFAVDK QRYQWYEELV RLLPGSYLGK LSLRQAPSLV
DLVVDAYKRL LSEVLVSVSV EDKAVSRYWV SVSPLCPDGS TPKGWSCTGV QPNQTVYFNI
TIGQHSCADD GKDEDVRVIV RPVGYNESTV VRIRSKCHCR CGTTGHCHED EQLPCQGPQD
GAKQEHLLHD NTDPSRSCRA SGADVDCSGR GMCVCGSCVC DQVRLGTIQG KYCEIDDFSC
PYKGGLICAG QGVCVLGQCV CEDGWSGDDC GCPLSTITCF SNGLLCNGQG KCVCGKCVCD
EPQRHGDFCE KCPTCQSTWQ SYCKSGTCLH SFGLSQKEVS MVSYMDNASE SASSGQLVRT
FLSVCALTVL CGLMVVAVSR LLLLKRGRSQ GVSEDGGYRC TGKDLSYIPT TNEKTVTYRR
DRPPDHPLEM HIQVPKMAFG DPWQC
//
