ID H2LGB8_ORYLA Unreviewed; 185 AA.
AC H2LGB8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=BHLH domain-containing protein {ECO:0000259|PROSITE:PS50888};
GN Name=twist1a {ECO:0000313|Ensembl:ENSORLP00000005013.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005013.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005013.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005013.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005013.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005013.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004073867.1; XM_004073819.2.
DR AlphaFoldDB; H2LGB8; -.
DR STRING; 8090.ENSORLP00000005013; -.
DR Ensembl; ENSORLT00000005014.2; ENSORLP00000005013.1; ENSORLG00000004012.2.
DR GeneID; 101173479; -.
DR KEGG; ola:101173479; -.
DR CTD; 30175; -.
DR eggNOG; KOG4447; Eukaryota.
DR GeneTree; ENSGT00940000163428; -.
DR HOGENOM; CLU_112073_0_1_1; -.
DR InParanoid; H2LGB8; -.
DR OMA; NCSYVAH; -.
DR OrthoDB; 5394263at2759; -.
DR TreeFam; TF315153; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000004012; Expressed in sexually immature organism and 8 other cell types or tissues.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR23349; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST; 1.
DR PANTHER; PTHR23349:SF103; TRANSCRIPTION FACTOR TWIST1; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 90..141
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 20579 MW; 837E8D1100339062 CRC64;
MREENSPPMD SAGNSEEETE RQLPRRGARK RRIARRSADE DDEADMESST CPGKKKCRKS
CEEGGGSAGS GSEASSSSSS PARSFDDLQT QRVMANIRER QRTQSLNEAF TSLRKIIPTL
PSDKLSKIQT LKLAARYIDF LYQVLQSDEL DARGTSCSYV AHERLSYAFS VWRMGGAWSL
STSSH
//
