ID H2LGE9_ORYLA Unreviewed; 1036 AA.
AC H2LGE9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Insulin receptor substrate 2a {ECO:0000313|Ensembl:ENSORLP00000005045.2};
GN Name=LOC101174984 {ECO:0000313|Ensembl:ENSORLP00000005045.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005045.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005045.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005045.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005045.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005045.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011482770.1; XM_011484468.1.
DR AlphaFoldDB; H2LGE9; -.
DR Ensembl; ENSORLT00000005046.2; ENSORLP00000005045.2; ENSORLG00000004036.2.
DR GeneID; 101174984; -.
DR KEGG; ola:101174984; -.
DR eggNOG; ENOG502QUNU; Eukaryota.
DR GeneTree; ENSGT00940000161407; -.
DR HOGENOM; CLU_004902_2_0_1; -.
DR OrthoDB; 4212441at2759; -.
DR TreeFam; TF325994; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000004036; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF7; INSULIN RECEPTOR SUBSTRATE 2; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 18..119
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 151..255
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 256..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 111983 MW; D29C533596135873 CRC64;
MASPPATGGH LSSTGTNDVK KCGYLRKQKH GHRRFFVLRE PTGSSPARLE YYESEKKWRN
KSAAKRVITL DSCLCVNKRA DAKHKHLVAL YTKDEYFAVA AENEQEQESW FSVLTDLIAE
GKAFDSPAST SSLVGFEEVS YGLLSSTTPV YKEVWQINMK SRGLGQTKNL TGVYRLCLSG
RNISFVKLNS ETAAVTLQLM NIRRCGHSDN FFFIEVGRSA VTGPGEFWMQ AEDSVVAQNI
HETILEAMKA MKELSEFRPR SKSQSASTNP ISVPTRRNLN NLPPSQTGLV RRSRTDSMAA
TSPGRRFTSS RIRTSSEGDG SVTRPVSMSI SVGGSPTSLN SGNHLCVFHT LSSGRTCRML
ESASNLHHSR SMPVSNSPPA ASSPVSSSPR LGTTISTPDK ARRPFSCSAS ISGSLSDTAF
MLCDDFSSSP CEPKFLSLTR SDTPDSLAST PPSRDTSDSY GYIVMEGSRC GGGVESLGND
KVYRKRTHSL TTPRQQRVAA PLASASLDEY TLMRMAQGQS SHSASPKVCY PEDYGDIEIG
SSRSSSSNLG DDGYMPMTPG VAPPSGKADN YVAMSPMCVS APKQIVNPRV HPQAAVNGGY
KTQSPCSGSL EDNGYMRMWC GSKSSVESPD RQAEYMNMSP GNPPPLQTPP DYGEPVAIRP
IYQSGSLTLP AKLQPRNEDD GQYVLMSPQS SRQQPGESDY YSVMQLTSPL SPSVPSPGRH
NRAENLQYRG RLGRPNRLSL DMLRTLPSMN ELPGEPRSPG EYINIDFSSG RSSPPSITST
ESQPSSLSSS GGGQGRPSLT DYINLDLGSR LPRGADAPAE RLDTLPELSS CPCSEDGEDQ
EDCGKTMLGE DVKTDYTEMT FGLTSPQLVC QNPSSCQSAR QLSWEDQSVQ ERIGVFLLGA
TVDPDCSAKV VRANPQGRRR HSSETFSSTA TVTPVFPSFA RGDNVKRPSS VENISSRSSE
CSDEESGSPV TRQSLTAFPT GLSYIAMNLL ETRDVEKCGD LVGFKPASSC KGGINGLHSA
PYACLGFQEA ATTAKD
//
