ID H2LGG3_ORYLA Unreviewed; 669 AA.
AC H2LGG3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Stromal interaction molecule 1a {ECO:0000313|Ensembl:ENSORLP00000005059.2};
GN Name=LOC101156837 {ECO:0000313|Ensembl:ENSORLP00000005059.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005059.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005059.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005059.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005059.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005059.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_004075351.1; XM_004075303.2.
DR AlphaFoldDB; H2LGG3; -.
DR Ensembl; ENSORLT00000005060.2; ENSORLP00000005059.2; ENSORLG00000004046.2.
DR GeneID; 101156837; -.
DR KEGG; ola:101156837; -.
DR eggNOG; KOG4403; Eukaryota.
DR GeneTree; ENSGT00390000000214; -.
DR OrthoDB; 54068at2759; -.
DR TreeFam; TF313487; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000004046; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd11722; SOAR; 1.
DR Gene3D; 1.10.238.180; -; 1.
DR Gene3D; 1.10.287.3550; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR032393; SOAR.
DR InterPro; IPR037608; STIM.
DR PANTHER; PTHR15136:SF9; STROMAL INTERACTION MOLECULE 1; 1.
DR PANTHER; PTHR15136; STROMAL INTERACTION MOLECULE HOMOLOG; 1.
DR Pfam; PF16533; SOAR; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..669
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017285650"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..431
FT /note="Stromal interaction molecule Orai1-activating
FT region"
FT /evidence="ECO:0000259|Pfam:PF16533"
FT REGION 588..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 241..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 588..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 75762 MW; 8B28886BACFD043C CRC64;
MELHKSVTLW VFFLCLIGES RTEKQVDGQT SDNGLSDFCR FDELLCKDEN ARLSFEAIRS
IHKQMDDDAN GNVDIVETDG FLREDLNYHD PKAKHNTFHG DDQFISVEDL WNAWKGSEVY
NWTVDEMVKW LITCVELPQY VDAFRKMNFN GSTMPRLAVK NTTLTLSILK ILDRSHVQKL
QLKALDTVLF GAPLMNRHNH LKDFMLVVSI VIGMGGCWFA YIQNRYSKDH MKKMMKDLEG
LQRAEQSLHD LQQKLQIAQE EHRTVEVEKV NLEQKLRDEI NAAKQEASRL RELREGTVNE
LSRQKYAEEE LEQVRMALKK AEKELESRCS WSPPESLQKW LQLTHEVEVQ YYNIKKQSAE
RQLLMAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL AAKQSLGEVT AALRERLQRW
HQIEFLTGFA IVNNPGLSSL IAALNLDPTF MGGRATPQHF PMSDDMDELD DCVMPGILQS
PSMVSLRKPH IDPQLAAGSQ RDLNRSDSDS SLSLSHFGER LSSASSRGHH VKPVSFMHGH
ADDTVSLHSL SHNGGNRILE EAAKETLCDS PILMKKFYDM EESPSLGDIH SFSESSRSFS
PNSTDPDTPS PSGGQIGIIG AKGSTRIPQL SSKKSPLEED SASTGDDTDS NASRKKLPFK
IFKKPRNKN
//
