ID H2LGM9_ORYLA Unreviewed; 151 AA.
AC H2LGM9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Nudix (nucleoside diphosphate linked moiety X)-type motif 15 {ECO:0000313|Ensembl:ENSORLP00000005127.2};
GN Name=nudt15 {ECO:0000313|Ensembl:ENSORLP00000005127.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005127.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005127.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005127.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005127.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005127.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family.
CC {ECO:0000256|RuleBase:RU003476}.
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DR RefSeq; XP_004066616.1; XM_004066568.2.
DR AlphaFoldDB; H2LGM9; -.
DR STRING; 8090.ENSORLP00000005127; -.
DR Ensembl; ENSORLT00000005128.2; ENSORLP00000005127.2; ENSORLG00000004095.2.
DR GeneID; 101166697; -.
DR KEGG; ola:101166697; -.
DR CTD; 55270; -.
DR eggNOG; ENOG502S3YT; Eukaryota.
DR GeneTree; ENSGT00390000003338; -.
DR HOGENOM; CLU_037162_9_2_1; -.
DR InParanoid; H2LGM9; -.
DR OrthoDB; 2914433at2759; -.
DR TreeFam; TF106353; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000004095; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0035539; F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; IBA:GO_Central.
DR GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR CDD; cd04678; Nudix_Hydrolase_19; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR020476; Nudix_hydrolase.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR16099; 8-OXO-DGTP DIPHOSPHATES NUDT15; 1.
DR PANTHER; PTHR16099:SF5; NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15; 1.
DR Pfam; PF00293; NUDIX; 1.
DR PRINTS; PR00502; NUDIXFAMILY.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003476};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 6..147
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 151 AA; 17190 MW; 5252FA6386FD149C CRC64;
MSDKPAKRPG VGVGVLVTDL AHPGCVLLGK RRSEMGRGTY QLPGGHLEFG ESWEECAVRE
VLEEAGVHLG KVRFASVVNS IRLEEQYHYV TIIMQGELDR RRSGEPENLE PEKNEGWTWT
RWDQFPPEQK LFLPLATLRK EGFQPFTETQ I
//
