ID H2LHI1_ORYLA Unreviewed; 951 AA.
AC H2LHI1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF5B {ECO:0000313|Ensembl:ENSORLP00000005443.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005443.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005443.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005443.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005443.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005443.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR RefSeq; XP_004080928.1; XM_004080880.2.
DR AlphaFoldDB; H2LHI1; -.
DR STRING; 8090.ENSORLP00000005443; -.
DR Ensembl; ENSORLT00000005444.2; ENSORLP00000005443.1; ENSORLG00000004344.2.
DR GeneID; 101173898; -.
DR KEGG; ola:101173898; -.
DR CTD; 3799; -.
DR eggNOG; KOG0240; Eukaryota.
DR GeneTree; ENSGT00940000154801; -.
DR HOGENOM; CLU_001485_11_1_1; -.
DR InParanoid; H2LHI1; -.
DR OMA; YYEHMRE; -.
DR OrthoDB; 5476186at2759; -.
DR TreeFam; TF105225; -.
DR Proteomes; UP000001038; Chromosome 20.
DR Bgee; ENSORLG00000004344; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:GOC.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0098971; P:anterograde dendritic transport of neurotransmitter receptor complex; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0048489; P:synaptic vesicle transport; IBA:GO_Central.
DR CDD; cd01369; KISc_KHC_KIF5; 1.
DR Gene3D; 6.10.250.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF73; KINESIN HEAVY CHAIN ISOFORM X1; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 8..325
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 901..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 413..528
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 624..802
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 931..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 85..92
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 951 AA; 108589 MW; E99B1C87A9223292 CRC64;
MADAAETTIK VVCRFRPLNS SEVARGDKYI PKFQGEDCVV IAGKPYHFDR VFQSNTTQVQ
FYNAVAQKIV RDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPDMMGIIPR IVQDIFNYIY
SMDENLEFHI KVSYFEIYLD KIRDLLDVTK INLSVHEDKN RVPYVKGCTE RFVCSPQEVM
DAIDEGKNNR HVAVTNMNEH SSRSHSIFLI NIKQENTQTD QKLTGKLYLV DLAGSEKVGK
TGAEGTVLDE AKMINKSLSS LGNVISALAE GSSYVPYRDS KMTRILQDSL GGNCRTTMVI
CCSPSSFNDA ETRSTLMFGQ RAKTIKNTVT LNVELTAEQW KKKWEKEKEK NKTLRNTVTW
LENELNRWRK GETVPVEEQF DKEKAKAEVQ DVDAGVTNDK PATKPSLGAL PGVKLTDAEK
QKYEAEMAKL YKEMDDKDDE INQQSQLVEE LKEQMLELEE LLGSSRRDHD TLQSELNRLL
AENEASKEEV KEVLQALEEL AVNYDQKSQE VEDKAKEFEA LSEELNEKSS CLTTIDSELQ
KLKEMTNHQK KRVTEMMSSL LKDLAEIGIA VGSNDIKQQE SSGVIDEEFT VARLYISKMK
SEVKTMVRRS KQLESSQAER SQTLQEAESE LTACQLRVSQ QEAKIKSLTD SLQNVEQKKR
QLQENVDLLN EEIVRIQAQE KVNAMEKENE IQSAHEVKEA VEKQIQSHRD AYQKQISSLR
DELDSKEKLV MELQDLNQQI VLEQERLKVE HEKLKAADQE KSRQLQELTV LQDRREQARQ
DLRGLEETVA RELQTLHNLR RLFVKDLSRR VRKNTQDSED SEDSSAQKQK ISFLESNLEQ
LTKVHKQLVR DNADLRSEIP KVEKRLRAMV ERVKALEAAL KEAKESAARE RKLYQQEMER
IKDAAKPKPN MGRRNSAQIA KPIRPGQLPG SSPLFSLNRS NIIRGGGNDS S
//
