ID H2LI91_ORYLA Unreviewed; 1306 AA.
AC H2LI91;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Pleckstrin homology domain containing A5 {ECO:0000313|Ensembl:ENSORLP00000005713.2};
GN Name=PLEKHA5 {ECO:0000313|Ensembl:ENSORLP00000005713.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005713.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005713.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005713.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005713.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005713.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8090.ENSORLP00000005713; -.
DR Ensembl; ENSORLT00000005714.2; ENSORLP00000005713.2; ENSORLG00000004545.2.
DR eggNOG; KOG0940; Eukaryota.
DR GeneTree; ENSGT00940000155728; -.
DR HOGENOM; CLU_008216_1_0_1; -.
DR InParanoid; H2LI91; -.
DR TreeFam; TF329090; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000004545; Expressed in pharyngeal gill and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; IBA:GO_Central.
DR GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IBA:GO_Central.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 11..44
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 56..89
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 169..268
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 124..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 776..803
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..954
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 148135 MW; 38322C69351DB603 CRC64;
MAAELQPEWI SALPSSWSYG VTRDGRVFFL NEEAKSTTWL HPESGEAVVT GHRKTPDLPT
GWEEGFTFEG ARCFINHNER KVTCKHPVSG LPSQDNCIFV INEQSASKVP ANEKKDRPQS
IMSEASNYTG SSDCTTNANS PAGRPSRSSK KIHNFGKRSN SIRRNPTAPV IKKNWLYKQD
SSGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFH ISKCAEDDHI NRKYAFKATH
PNMRTYYFCT DTAKETESWM RVMTDAALVH SGPVKSTATQ EQMGLNAQRL STGMGVCSSG
VDQLKVGQCG PQETHHVANH KPPLTQPEIQ NNQRNKESAC EHIVPVPSST DEEERKQRDA
ERYGFHKDGS QRERPLTKIS SIKLPPVQAE TVKSNVTSPQ PLTEVDRPYQ APQVNGSEEL
RPPEGTGFPQ QQSSTGDPVR SLSRTNSMQQ LEQWVRTQRG RNQDEDTRSI TSYQTLPRNM
PSHRVPYMPA YGDGYRSMPR NSMAQRDSIC SMSPSLYDQA LGPCAAEKRR SMRDDTMWQL
YEWQQRQAYT RQSGLYSGMP SPKTMVNLSE HAAPNHSIPP SPSHGSLSMY GGYSPMRSYS
MASARSEVSS PVYRRDMSID RRHRPPINKY IYPPDRRSMP AGIPVQTITA QSLQGKTPEE
LTLLLIKLRR QQAELNSIRE HTVAQLMQLN MDGDNPKNDI LSHHLQRNLM YLDNQIKEND
PLIVMTHSLI ENSAPRPQLY QQLSPEDYRE QAYTCVPEEV DTDTKLSRLC EQDKVVRAQE
DKLQQLYREK HTLETALLSA SQEIELGPEN PATLQSVIQQ RDLLQSGLLS TCRELTRVTS
EVERSWREYD KLEADVILAK NNLLEQLEAL GSPQTEPPSQ EHVRIQKDLW RIQDVMDVLN
KHKEQRNAFD EMGFGGPKAN FSKHKNEAED LVPPRPPLPQ SYEPNSPIAP PLPSHAGVRP
SSLHRPEDRK ANQRNGTHSG PDYRLYKSEP ELTTVTEVDE NKDEDRSEST DREHAAGKGM
SYPVGIVPPR TRSPVPESSS IASYVTLRKS KKPDPRTERP YSAMEQQLSA VEGNRPRMSV
EEQLERIRRH QQGTLREKKK GARIRSSSQD NTPSRSHSFA GYNHFHSTQS HMRRRDQMMS
SNIQELEASL RQQEVVRRQE TPSEEIARLK ESLQAEDFNV DRELSVPDKV LIPERYIESD
PEEAPSPEQE ADKQRKVDRI KALIAKNSMQ NVLPSLALSP EEDHEEEVTI LEKEKMINIS
YELAAEASKR SKLVAVKSLS SSSSPPFPQS PNTASQLTDG SHFMCV
//
