ID H2LJF1_ORYLA Unreviewed; 351 AA.
AC H2LJF1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Atonal bHLH transcription factor 1a {ECO:0000313|Ensembl:ENSORLP00000006139.2};
GN Name=atoh1a {ECO:0000313|Ensembl:ENSORLP00000006139.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000006139.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000006139.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006139.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000006139.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006139.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004072375.1; XM_004072327.2.
DR AlphaFoldDB; H2LJF1; -.
DR STRING; 8090.ENSORLP00000006139; -.
DR Ensembl; ENSORLT00000006140.2; ENSORLP00000006139.2; ENSORLG00000004876.2.
DR GeneID; 101170025; -.
DR KEGG; ola:101170025; -.
DR CTD; 30303; -.
DR eggNOG; KOG4395; Eukaryota.
DR GeneTree; ENSGT00940000160064; -.
DR HOGENOM; CLU_083039_0_0_1; -.
DR InParanoid; H2LJF1; -.
DR OrthoDB; 5406645at2759; -.
DR TreeFam; TF315153; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000004876; Expressed in embryo.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0042668; P:auditory receptor cell fate determination; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR GO; GO:0035675; P:neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0048663; P:neuron fate commitment; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048923; P:posterior lateral line neuromast hair cell differentiation; IEA:Ensembl.
DR GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR CDD; cd19713; bHLH_TS_ATOH1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR032661; ATOH1_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290; BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED; 1.
DR PANTHER; PTHR19290:SF82; TRANSCRIPTION FACTOR ATOH1; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 152..204
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 27..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 37853 MW; 1FE0CC8CC0DE3C3F CRC64;
MDVLSLEDWS NGAREVAALR AQQQCCSSPG AAGRAGKQQM EESSYESGLT LVDSGSDPRA
WLAPASGNCE THEYLRHSPY SSNCSYNEAD SPGSSGHPSP PSHRKSAKSP SSPSLKVRDL
CRLRGASTGG KDEASVRHRA PSSKPINGIQ KQRRVAANAR ERRRMHGLNH AFDELRSVIP
AFDNDKKLSK YETLQMAQIY INALAELLEG PSNTEDSSSI SPERDSMLSS PETTDRAPPS
PRTTPAPAPV TGGTLPVHIG GMPFRSSFEE SSFPAKAGDE LSAPSPSSSM RAAASQFSRG
RKGSPRSDGE FSPHSHFSDS DEIALELHSS EEDDLSELKL PSHHHQHTLP F
//
