ID H2LKX8_ORYLA Unreviewed; 998 AA.
AC H2LKX8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF5A {ECO:0000313|Ensembl:ENSORLP00000006686.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000006686.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000006686.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006686.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000006686.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000006686.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR AlphaFoldDB; H2LKX8; -.
DR Ensembl; ENSORLT00000006687.2; ENSORLP00000006686.2; ENSORLG00000005301.2.
DR eggNOG; KOG0240; Eukaryota.
DR GeneTree; ENSGT00940000159439; -.
DR HOGENOM; CLU_001485_11_1_1; -.
DR TreeFam; TF105225; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000005301; Expressed in sexually immature organism and 4 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01369; KISc_KHC_KIF5; 1.
DR Gene3D; 6.10.250.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF73; KINESIN HEAVY CHAIN ISOFORM X1; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 9..327
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 955..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 332..373
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 410..511
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 643..677
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 701..780
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 824..879
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 86..93
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 998 AA; 114505 MW; 6DEA78FC7E184651 CRC64;
MADSNAECNI KVLCRFRPLN QSEIIRGDKF IPVFQGDDTV IVGGKAYVFD QVFPAKASQE
EVYNSCAKHI VKDVLGGYNG TIFAYGQTSS GKTHTMEGNL HDPQEMGIIP RIAEDIFDHI
FAMDENLEFH IKVKSRPVVF FIFPHVTAVT KINLSVHEDK YRVPYVKGCT ERFVTCPEDV
MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EQKLSGKLYL VDLAGSEKVS
KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKSHVPYR DSKMTRILQD SLGGNCRTTM
FICCSPSSYN DTETKSTLMF GQRAKTIRNT VTVNLELTAE QWKKKYEKEK ERSRMMKETI
QKLEAELNRW KNGENTIVLE KLSEAESEDT PYMTADPEEA ALDASSSIVV HISDEERQKY
EEEIRKLYKQ LDDKDDEINN QSQMVEKLKE QMLNQEELLA SSRGDSEKVQ YELGKLQTEN
ESAKAEVKEV LQALEELALN YDQKSLEVEE KSVQNKLLAE ELAKKMAHLI AVEAELSHIQ
EVSSQQRKRI IEIINGLMKD LREFSTIVGN KEIKLPIDRT GAIEEEFTVA RLFISKIKSE
VKSMVKRCRH LENLQVECHR KMEETSRELS SCHLLNSQHD AKIRHLSDYV QNLELKKRQL
EDSYDSLTEE LAKLQAQGNN EVKTNSLIVC QALDQQMESH HEAQRKQLSR LRDEISEKQK
IIKELTDCNQ RQQLELEQLR SDSERFRLQD HEKSRQLEEL TFLNERHEQS KQDLKGLEET
VARELYTLHN LRKLFVQDLT TRVRKSADME HNESGGFLTQ KHKISFLENN LEQLTKVHKQ
LVRDNADLRC ELPKLEKRLR STAERVKALE GALKEAKEGA IKDRHHYQQE VERIKDVMRT
RNPFRRPHAA QIAKPVRPGH YPVCTPSNPF FIRGYSEHPI AFCNAVFYNK NSQPTLASAA
PPRPAAEVRL EEVNSNQNTP EELFDSQNMD DHDTQNNK
//
