ID H2LMB7_ORYLA Unreviewed; 3155 AA.
AC H2LMB7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Vacuolar protein sorting 13 homolog A {ECO:0000313|Ensembl:ENSORLP00000007188.2};
GN Name=vps13a {ECO:0000313|Ensembl:ENSORLP00000007188.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007188.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007188.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007188.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007188.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007188.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR STRING; 8090.ENSORLP00000007188; -.
DR Ensembl; ENSORLT00000007189.2; ENSORLP00000007188.2; ENSORLG00000005718.2.
DR eggNOG; KOG1809; Eukaryota.
DR GeneTree; ENSGT00950000183083; -.
DR HOGENOM; CLU_008365_0_0_1; -.
DR InParanoid; H2LMB7; -.
DR TreeFam; TF335791; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000005718; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..354
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 549..772
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1118..1297
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1897..2435
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2746..2923
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2928..3015
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3017..3123
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 776..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3155 AA; 356322 MW; BAFD545AC138C5F6 CRC64;
MVFESLVVDV LNRFLGDYVV NLDSSQLKLG IWGGDAVLKS LEIKENALSE LDIPFKVKAG
HIGRLELKIP WKNLYTQSVE ATLDGVYLLI VPTASIKYDA EKEEKQLQEA RQRELQRIED
TKRKAAEQDD PQQEKQDSFM EKLVTQVIKN LQVKIANIHV RYEDNVSIQT SDKNWKPSLL
DENARLFFKL VKLENLFAYW NVNSVLFSTQ SAEEALRSLE NSMTIQKSPA ANHDFIIRPI
SADAKLKMNP RSDVDFSSPK VDLMVNLSEV AIELNKPQYI SILELLDSVD MMSRNLPYRK
YKPVVQVHQN AGTWWKYCIT SILEVNVKPH LHMWSWQHIR RHRATVQCYK EFYKTKITCK
KPSDNLLKDL ENTEKALDIF NITLARRQAE VEASKAGLRI YRPGVKMEEE ESQGWFSWVW
NWGGEQKETK NNFGNIISKA KLYTAIGYSE TAANPNLPKK FEDMKVNFHM ERLCVSIKDE
KDKNEVMRLT VGELKSTLTQ RPGAQAIKIT AELSLFEVTG LASNRPAPTL LSSRRAATKT
GTPLLIILFE TNPLDESADQ RFHVSSQPLE IIYDALTVNS VSEFFRLPDD VQLNEFTKAT
LMKLEQFKDR TATGLLYVIE TQKVLDLKVN LMASYVIVPQ SGFYDGTQNI LLLDLGHFKM
ASQSKENLPQ LTPCPSNIEA IMSRAYDTFD VQLSSLQFLY SKPGGDWKKA RKQKQSPLHI
LEPVDVNVDF SRAMVVKDSR MPKYKVLGEL PLLSLRISDI KLRNVLELVD SIPLPESKPS
AHNTAPSSTQ KVRPALSQNR KSLKFSEFDL TEDLFYDAPS SPVGDDSFFP DNPLPLRYVD
SRNRRSLIKE DVQKNMTEFL MTFLINEFSV QLCRMSEGQE VTVLHLDIEG LGTELQLRTF
DMTSNTYLRE ICLTCPEYVD MEQKQVQLIT TLDNSEDDLL TLEYIKADKN GPEFKSLHNN
TEQMIKVTFS SLDVHLHTEA LLNTINFLSN LLPPSTKTNE VLEAEGEEER EGEKKGESKF
ADVVNMHIRA DLRCLKVFLR GQKARISEIR VEGLVSEVLQ RKKMMEVSAN LKNIVVLDCN
KEASYKKAVS IADKEVFAFR MLNYTDATEG DGYLNMSNVD TSVTLTVGCI QVIFLNKFLD
SILAFINNFQ MAKEAIAEVT VQAAEKAASG VKELSERSTR ISLEVHFNAP VIFLPQSSSS
SNVIVADLGK LSVKNRFVKQ PFKSDSTIPP VVDKMTVKLS DLKMYRTTYI SGIFKGESQL
LKPVSLDLEI QRNLSSNWYH NIPDIEISAH LKPMSLILCQ DDMIVVLRTL GENLSEKSDA
VSPLPDLPSA KESQNSGASG SDSNIVVTAA VVETQKYVKL KTTLKLEFKF DSMTVVLHSP
NKNEMEMLDL HHEQLKLAEF TLGTISTSVQ MFSDSSMKAF VQLTACQLDD KRPSIKMVTS
RMVAMRPGAE QNTMMEVNYR QGHDGTTIDT VVQDLYLCAS MEFLLTVADV FLKATQQGFA
QGPQAKSTAG TSPVSKTEMN VVVRNPEIVF VADLSRADAP ALVMTTQCEL DMKNGADGQM
MTAIIKDLQV MACPFLTSKR GNNMTTVLQP CQVFFQSSQH PDAPQVMEVS INALSLKVSP
IIINTVITIQ SALTPTTETH EEERSLVPVK LWEKQSWKEL KMWFLEENSD EDTKSLVPLI
PKGESLQVTI NSICLTLEAG VGHHTVPMLL AKSSFDGNVK NWTTLINLKS KFDLEVHYYN
EMMGVWEPLL EPLEDETGED FRPWTLELKP MNLSDIADEV DFNLPDYKTV IVFNSKDQLN
ITLTNCGLSM LSNLGKAFSE AAKQTADSFQ KDEAPFVVKN MLGLPVSLQL SKRFHLVGKQ
TTNNAVTLQS DETLRMNYSS RPDSDQFSAM ISLSEKDYYI QPTPVGHTST SVIPLIKVGR
GMYSVMHKDS RVTRFLVCQI SSVDGSKIVK IRSPFQIINH FSIPFKVFDD SACLGIALPN
EEFCVPLDSY RSVLSLQPVT EGDSGLQREE FECSEGFSYE DSNNPHFQQT CCHHGDQGVK
IIVNIVPVKD TVTFKNTGDA GENYDVPFVL HLWPSVLLHN QLPYQITYRL KETGVSAPEA
ILKPGHSTQL HTAVINQSQL ELRLIDYLSQ DWSSEYSISS NQEEISFIVF QSLKEEEDEY
VEGTERKKAE LDIAVHVKDD SGHTAIAIHS PYWMMNKTGR LLQYNADDIH HKHAFTKNND
MPLLFSFKPR HFLRNNKVRL MISESELSDE FSLDTVGSHG KVKCKGIHKD YLVGVKINAS
SFSLTRIVTF VPFYTLVNKT KYKIFICEDE GDTWTEINPE QPATPFWPEN GTKKLKIKVD
GCLTPPLKVD FTRQENSLLL HLNDSLGGII VDVNLSEHLV TIQFSEYRDG SAPFLIINHT
NDQTLYFNQS SQKEIEKEEL EAGKAVYYTW TDPTGSRELC WTCGPYSGTL KTEEDLHDDM
KDERKLFVIS FFEGLQRVVV FTEDQDIYNL LGESEKIQAA EQEIILLLQN VGVSLVNNTT
SQEVSFIGIT CSDVVWESQP RKKKRWKILN IKEGDMLEKH FKEYINSSPI EDAIVELENN
YKVRFTSNGV DMRMLQPFDA PLRRHFLPGI KVEYSISPRQ STYRVKIHRI QIQNQMQSAI
FPYVFYPVKL PKSITMDSEP KPLIDICIVT RAAGHSEIPR IKYFKVLIQE MDLKLDLGFL
YSIFDLVNPE NTTSMSPVEL FEKDIEYIKT DLNDVSAADT SPISLYEFFH ISPIKLHFSF
SLSSGGEDGS KEKRATEVIP VQSLNLLLKS IGATLTDVQD VVFKLPAFEL KFQFCTTQQL
QWKVIRHYSK QAIKQAYVLV LGLDVLGNPF ALIRGLSEGV EAFFYEPYQG AIRGPEEFVE
GMALGAKVFV DKAVGGLAGA AFKMTGAMAK GIAAITMDED YQQKRREAIN RQPSGLKEGL
ARGGKGLVSG FVSGITGIVT KPIKGAQKEG AVGFFKGCGQ GLVGAIARPT GGIVDMASST
FQGIKRAAEA SQNVESLRPP RFIHEDGVIR PYKAREANGS QMLQKIENGR FAKYRYFAHA
NINESDFLMI TKRGIFFVTR GTFGQLTCEW QYLFEEFTMD PRIDGGRRLR IEAKERVKSV
FHAKEFGKII NFRTPEVANW VLEKLKDARD SLSKY
//
