ID H2LMF8_ORYLA Unreviewed; 1490 AA.
AC H2LMF8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Slit homolog 2 (Drosophila) {ECO:0000313|Ensembl:ENSORLP00000007229.2};
GN Name=slit2 {ECO:0000313|Ensembl:ENSORLP00000007229.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007229.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007229.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007229.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007229.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007229.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSORLT00000007230.2; ENSORLP00000007229.2; ENSORLG00000005750.2.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000158402; -.
DR HOGENOM; CLU_001431_2_0_1; -.
DR TreeFam; TF332887; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000005750; Expressed in sexually immature organism and 11 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF2; SLIT HOMOLOG 2 PROTEIN; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00274; FOLN; 2.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1490
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017274605"
FT DOMAIN 873..908
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 910..949
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 951..987
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 989..1027
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1029..1065
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1074..1110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1113..1288
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1292..1323
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1326..1362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1368..1404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1409..1489
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 898..907
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 939..948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 977..986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1017..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1055..1064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1100..1109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1313..1322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1330..1340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1352..1361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1372..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1394..1403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1490 AA; 164018 MW; A8C278EB5665C2B1 CRC64;
MVGALRPAAY SRSLATVSGL LVITILLSSG ADAQPCPTQC SCTGTTVDCH GQGLRSVPRN
IPRNTERLDL NANNLTKITK ADFAGLRHLR VFDLSENQIQ GVPRKAFRGA VEIKNLQLDY
NHISCIEDGA FRALRDLEVL TLNNNNISRL SVASFNHMPK LRTFRLHSNN LQCDCHVAWL
SEWLRQRPRL GLYTQCMSPP HLRGHNVAEV QKKEFVCTGH QSSSSSSCSV LQCPESCTCS
NNIVDCRGKG LTEIPTNLPE TITEIRLEQN AIKVIPAGAF SPYKRLRRID LSNNQISELA
SDAFQGLRSL NSLVLYGNKI TEISKGLFEG LFSLQLLLLN ANKIACLRVD AFQDLHNLNL
LSLYDNKLQT IAKGTFSSLR AIQTLHLAQN PFICDCHLKW LADYLQDNPI ETSGARCTSP
RRLANKRIGQ IKSKKFRCSG TEDYRSKLGG DCFADLACPE KCRCEGTTVD CSNQKLTKIP
DHIPQYTAEL RLNNNEFTVL EATGIFKKLP HLRKINLSNN RITDIEEGTF EGASGVNELI
LTSNKLENIH HSMLKGLGGL RTLMLRSNRI SCVSNSSFVG LSSVRLLSLY DNQVTSMTPG
AFDTLHSLST LNLLANPFNC NCHLAWLGDW LRRKRIVTGN PRCQNPYFLK EIPIQDVAVQ
DFACEDGNNE NSCSPVMRCP AECSCLDTVV RCSNKGLTTL PKGLPKETTE LYLDGNHFTQ
VPVELSNYKH LTLIRTFKNM LPQKFLKVSM PTCLFRVQRI LSYNRLRCIP VRAFDGLKSL
RLLSLHGNDI SLIPEGAFKD LSSLSHLALG ANPLYCDCHM QWLSDWVKSG YKEPGIARCA
GPGDMTDKLL LTTPSKKFTC TGPVDLSIQA KCEPCLSNPC KNDGTCTNDP VHYYRCTCPY
GFKGQNCEDP IHACISNPCQ NGGTCHLKEG DGSNFWCVCP EGFEGDSCEI NIDDCEDNDC
ENNSTCVDGI NNYTCMCSPE YTGELCEEKL DFCAPELNPC QHDSKCILTP QGYKCECTPG
FVGEHCELDY DDCKDNKCQN GAQCIDAVNG YTCVCSEGYS GLFCEFAPPM VLPRTSPCDN
HECLNGAQCV VVGTDPRCQC LHGYEGERCE TLVSVNFVNR ESYLQLPSNL LSPQTNISLQ
IATDEDSGVL LYKGDNDHIA MELYRGRLRV SYDTGSYPPS AIYSVETVND GSFHAVELVA
AEQTLSLSID GGPPKSIGSI NKQSTLNIDS PLYLGGMPER AFASGGFSAL QHSPGGHNGT
SFHGCLRNLY INGKLQDLGA GLDLGPGCQP CQRDTCVSGD CHPTGQRGFT CTCHPGWTGT
LCDQQVSNPC DGNKCIYGTC VPINSYSYSC RCQPGFTGVL CDERDHDTVN SCSLSHCKHG
KCRVSGLGKA YCECNSGYTG EACDREVACR GERVRDVYQR QQGYAACQTQ EKVSRLECRG
SCPGGSEGQG SCCTPLRSKR RKYTFHCTDG SSFVQEVEKV VKCGCTKCSS
//
