ID H2LN38_ORYLA Unreviewed; 915 AA.
AC H2LN38;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF18A {ECO:0000313|Ensembl:ENSORLP00000007463.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007463.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007463.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007463.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007463.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007463.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR AlphaFoldDB; H2LN38; -.
DR STRING; 8090.ENSORLP00000007463; -.
DR Ensembl; ENSORLT00000007464.2; ENSORLP00000007463.2; ENSORLG00000005936.2.
DR eggNOG; KOG0242; Eukaryota.
DR GeneTree; ENSGT00940000159058; -.
DR HOGENOM; CLU_001485_21_5_1; -.
DR InParanoid; H2LN38; -.
DR TreeFam; TF105231; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000005936; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0061673; C:mitotic spindle astral microtubule; IBA:GO_Central.
DR GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01370; KISc_KIP3_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF13; KINESIN-LIKE PROTEIN; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 32..376
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 635..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 134..141
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 915 AA; 104048 MW; 54DC0716CEE1E191 CRC64;
MLSINIYTFH YLVCRYSPAT SGSTMANDVC SHVKVVVRVR PTNDSEKREN FRNVVQVVDN
HMLIFDPKEE NLSCFGPQRV RNRNINKRAN KDLKFVFDRV FDENSTQVEV FENTTKGVLD
GVMNGFNCTV FAYGATGAGK THTMIGSPDD PGVIYRTMKE LFKRMEDVKE EKEFAVTFSY
LEVYNEQIRD LLANAGPLNV REDSSKGVVV QGLTLHQPKS AEHLLEALDS GNRNRTQHPT
DMNATSSRSH AVFQIYLRQQ DKTASLNQNV CMAKMSLIDL AGSERASATN AKGARLREGA
NINRSLLALG NVINALADPK SKKAHIPYRD SKLTRILKDS LGGNCRTVMI ANVSPSSKSY
DDTHNTLKYA NRAKEIKTSL KSNVVSLDSH IGQYAVICEK QRKEILQLKQ KLKEYEAKRE
EPGSLSLISS QKLAEVSEAL QQIFSSRGQI RREQLDLERQ LKENELRQRY SEEDNLQVQY
FCAKEKTEKA TCKHERKIAS LRTQQKHTCQ RLKEAEARFL ENDGLLHRVE NEMKLLKTND
QTSEVLEKDL HCHRLELQVN DLQQHVKQMV QLTLLQDQEN KRVHKMVNIL LPAFSRHYAI
LHRNGLATEK DERENQELEH LVLRERGVVW ADQSLQQRKG ERNLESQETN EEGRTELRSE
LAPILTFSHL QYHQSSPCSR SCSSSFDLSS FPDPTQDRPP RMPIRRNLSA LLPPQSPRSA
AESQSLEDDM FPLQCTPEPV PKTVPAQPSS SHSYMDPNKT FEIPEHDEAA SNVTITINCS
SPLQAPKSTI CGQTWDLPRA AEGNPVTSKS LQQIPPLQDV RRAKPTYMTM TSAAQGKRKF
NRNSYFNEVS SGSFRSEADK KRPLCHPEAS QSSENRSRRV VRSISEGNLN LLEPPKSRPL
FYKTSQQLKR LTKRM
//