ID H2LNA1_ORYLA Unreviewed; 439 AA.
AC H2LNA1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=VWFD domain-containing protein {ECO:0000259|PROSITE:PS51233};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007528.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007528.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007528.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007528.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007528.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LNA1; -.
DR STRING; 8090.ENSORLP00000007528; -.
DR Ensembl; ENSORLT00000007529.2; ENSORLP00000007528.2; ENSORLG00000005986.2.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000164871; -.
DR HOGENOM; CLU_030159_1_0_1; -.
DR InParanoid; H2LNA1; -.
DR TreeFam; TF351188; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000005986; Expressed in intestine and 3 other cell types or tissues.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF399; MUCIN-2; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 2.
DR SMART; SM00832; C8; 1.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS51233; VWFD; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..175
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 365..439
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 439 AA; 49965 MW; 2942761B67057C13 CRC64;
NHVSSICSTW GREHFKTFDG DVYQFPGLCE YNLVSDCHEL YQEFSVHLKR TEQDGKPTVS
YVLVTVNDLY FHITKTRVVV NSELVTLPYY QGGVQVEKNA VYTKLQAKVG FTVMWNGDDA
VMVEIDNDYA NRTCGLCGDF NGFPVYNEFM HNGRKISPIE FGNKHKAHRP NDDCEDPYEE
EELLQTKTVD ESCKEFRTPC EQMLIAESWS SCIKLIDPEV YIQACVLDMC GCSNSSDDFC
VCSTLSEFSR QCSHAGGQPP NWRSPQFCDK QCPYNMVFEE SGSPCMDTCT HQDTSSLCEE
HKIDGCFCPP GTVFDDISMR GCIDKSDCQC KHINIYDAGQ VYRQDTEECT CFEGRWICVS
LQRRALCSVE EGSHFTTFDG KAYTFHGDCY YTLAKVERKD EISPKFTILA QLVPCAHQQF
DTCLKTLKVL VNNDRNNVS
//
