ID H2LNX8_ORYLA Unreviewed; 1853 AA.
AC H2LNX8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Myosin heavy chain, fast skeletal muscle-like {ECO:0008006|Google:ProtNLM};
GN Name=LOC101158198 {ECO:0000313|Ensembl:ENSORLP00000007758.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007758.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007758.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007758.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007758.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007758.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8090.ENSORLP00000007758; -.
DR Ensembl; ENSORLT00000007759.2; ENSORLP00000007758.2; ENSORLG00000025497.1.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000162888; -.
DR HOGENOM; CLU_000192_13_0_1; -.
DR InParanoid; H2LNX8; -.
DR TreeFam; TF336753; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000025497; Expressed in bone element and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..698
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 575..597
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 762..1575
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1604..1842
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1853 AA; 213345 MW; 7953FA65068AF641 CRC64;
MSTDAEMEAY GPAAIFLRKP ERERLEAQTA PFDAKTAFFV AEPEEMYLKG KLIKKEGGKA
TVETITGKTL TVKEEDIHPM NPPKYDKIED MAMMTHLNEP TVLYNLKERF ASWMIYTYSG
LFCVVVNPYK WLPVYDAQVV NAYRGKKRIE APPHIFSISD NAYQFMLTDR ENQSILITND
NSSRFGKFIR IHFGTSGKLS SADIETYLLE KSRVTFQLSA ERSYHIFYQL MTGHKPELLE
ALLITTNPYD YHMISQGEVT VKSIDDIEEF IATDTAIDIL GFSLEEKLGI YKLTGAVMHH
GNMKFKQKQR EEQAEPDGNE VADKIAYLMG LNSADMLKAL CYPRVKVGNE MVTKGQTVPQ
VNNSVSALCK SVYEKMFLWM VIRINEMLAT KQPRQFFIGV LDIAGFEIFD YNSLEQLCIN
FTNEKLQQFF NHTMFVLEQE EYKKEGIEWE FIDFGMDLAA CIELIEKPMG IFSILEEECM
FPKASDATFK NKLYDQHLGK NKAFEKPKPG KGKAEAHFSL VHYAGTVDYN VTGWLEKNKD
PLNDSVVQLY QKSSNKLLAL LYASHASTEG FKENLGKLMT NLRSTHPHFV RCLIPNESKT
QGLMENFLVI HQLRCNGVLE GIRICRKGFP SRILYGDFKQ RYKVLNAAVI PEGQFMDNKK
ASEKLLGSID VDHSQYKFGH TKVFFKAGLL GTLEEMRDEK LASLVTMTQA LCRGFLMRKE
YVKMVERRES ILTIQYNVRS FMNVKNWPWL KLYFKIKPLL QSAETEKELQ EMKGNYEKMK
TDLAAALAKK KELEEKMVSL MQEKNDLQLQ VSETDNLSDA EERCEGLIKS KIQLEAKLKE
TTERLEDEEE INAELTAKKR KLEDECSELK KDIDDLELTL AKVEKEKHAT ENKVKNLTEE
MASQDESIAK LTKEKKALQE AHQQTLDDLQ AEEDKVNTLT KAKTKLEQQV DDLEGSLEQE
KKLRMDLERA KRKLEGDLKL AQESIMDLEN DKQQSDEKIK KKDFEISQLL SKIEDEQSLG
AQLQKKIKEL QARIEELEEE IEAERAARAK VEKQRADLSR ELEEISERLE EAGGATSAQI
EMNKKREAEF QKLRRDLEES TLQHEATAAA LRKKQADSVA ELGEQIDNLQ RVKQKLEKEK
SEYKMEIDDL SSNMEGVAKS KGNLEKMCRT LEDQLSELKA KNDENVRQLN DLNAQRARLQ
TENGEFARQL DEKEALVSQL TRSKQAFTQQ IEELKRHVEE EVKAKNALAH AVQSARHDCD
LLREQFEEEQ EAKAELQRGM SKANSEVAQW RTKYETDAIQ RTEELEESKK KLAQRLQEAE
ESIEAVNSKC ASLEKTKQRL QGEVEDLMTD VERANSLAAN LDKKQRNFDK VLAEWKQKYE
ESQAELEGAQ KEARSLSTEL FKMKNSYEEA LDQLETMKRE NKNLQQEISD LTEQLGEIGK
SIHELEKAKK SVETEKCEIQ TALEEAEGTL EHEESKILRV QLELNQVKGE IDRKLAEKDE
ELEQIKRNSQ RVIESMQSTL DAEVRSRNDA LRVKKKMEGD LNEMEIQLSH ANRQAAEAQK
QLRNVQGQLK DAQLHLDDAL RGQEDMKEQV AMVERRNGLM LAEIEELRAA LEQTERGRKV
AEQELVDASE RVGLLHSQNT SLLNTKKKLE SDFVQVQGEV DDAVQEARNA EEKAKKAITD
AAMMAEELKK EQDTSSHLER MKKNLEVTVK DLQHRLDEAE NLAMKGGKKQ LQKLESRVRE
LESEVESEQR RGADAIKGVR KYERRVKELT YQTEEDKKNV ARLQDLVDKL QLKVKAYKRQ
TEEAEEQANT HMSRLRKVQN ELEEAQERAD IAESQVNKLR VKSREAGRVT FLF
//
