ID H2LP03_ORYLA Unreviewed; 490 AA.
AC H2LP03;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
GN Name=mazb {ECO:0000313|Ensembl:ENSORLP00000007783.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007783.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007783.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007783.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007783.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007783.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LP03; -.
DR Ensembl; ENSORLT00000007784.2; ENSORLP00000007783.2; ENSORLG00000006188.2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158525; -.
DR HOGENOM; CLU_042232_2_0_1; -.
DR InParanoid; H2LP03; -.
DR TreeFam; TF331686; -.
DR Proteomes; UP000001038; Chromosome 19.
DR Bgee; ENSORLG00000006188; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384:SF189; DEFORMED WINGS-RELATED; 1.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13894; zf-C2H2_4; 2.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..490
FT /note="C2H2-type domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017214536"
FT DOMAIN 75..102
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 229..256
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 257..284
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 287..315
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 316..343
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 369..396
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 32..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 53215 MW; E30D1DEBC1A20C4E CRC64;
LHLVMAFLLL QSTPTQNQVE GSLQSELMQV HTSSPQTPPT EHIAQPPSTV DTTALSEEPL
PVPVKPVSRT ARAQHICAIC NKQFKNNYNL RRHQSVHTGV RMKDRAREAE RPAVPLSLLH
LSAPPPLAPP GVLAGAQQTP LGGRDGEGIA MANVMASVNP HAPPPAAVVM ATGATVQVGQ
GLVETAVVKP KPSSTLFLKL PPPLKSPPHC PSPPRRPANP NPNPVKKNHA CETCGKAFRD
VYHLNRHRLS HSDEKPFSCP ICQQRFKRKD RMSHHVRSHQ GGVEKPYICP HCGKAFSRPD
HLNSHVRQVH SSERPFKCPT CESSFATKDR LRAHMIRHEE KVPCHICGKL LSAAYITDHM
RVHNQSQHHV CHLCNRSFTT LTYLRVHAQK HHGQEWKESP GGFGGAASGS VLVCHLCGVH
CKTPTQLQGH MGTHSNSQAA PSPVTSNVAA SSSVSLSNMV TAPTVYVTGN TVVDLLVTDC
SSIAAPQTHS
//
