ID H2LP37_ORYLA Unreviewed; 905 AA.
AC H2LP37;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ano5b {ECO:0000313|Ensembl:ENSORLP00000007817.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000007817.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000007817.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007817.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000007817.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000007817.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_004067171.1; XM_004067123.2.
DR AlphaFoldDB; H2LP37; -.
DR Ensembl; ENSORLT00000007818.2; ENSORLP00000007817.2; ENSORLG00000006218.2.
DR GeneID; 101167353; -.
DR KEGG; ola:101167353; -.
DR CTD; 560102; -.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000155692; -.
DR HOGENOM; CLU_006685_1_4_1; -.
DR OrthoDB; 534027at2759; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000006218; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF45; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 289..316
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 452..477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 497..520
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 547..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 723..742
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 59..275
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 278..859
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 905 AA; 106136 MW; 64E2DB7AF2020301 CRC64;
MRRITGNAKE ETLIELQSAA DSQITDDSSG NGVGVLSERA QLPGHIETDK LQPTRDTVFF
RDGVRRIDFV LSYVDDKDEK KQERRRAFEA NLEKTGLQLE TEDKSDSKDQ KTYFLKIHAP
WDVLATYADV LKIKVPFRES DIPHGQDVPL EWLSRPFRLP DDIIRPQCDY FTYPFDKNKT
DFFLIEDKDT FFPPSTRNRI VFYILARCPY YAEGRKDWEK TGIKRLLSNG TFNAAFPLHD
CRYWKKARKD DGESERYNLY KHWARFLCFY KEQPLNLIRK YYGEKIGIYF AWLGFYTEML
FFAAVMGLIC FTYGVLSYDD NISSKEICDP DIGGSIVMCP LCDKKCPFWK LNSTCLSSWQ
SHLFDNEGTV FFAIFMGIWV TLFLEIWKRR QARLEYQWDL VDFEEEQQQL QIRPEFEIKC
TKRRINKITQ ESEPYLPFSS KCARFSLSAT TVLLWISLIV ACIIGVIAYR LAVYAAFASI
IKDPLRKIQL VGRFITPQLA TSVTASCINF AIIMILNFFY EKVAVWITDM EIPKTHLEYE
NKLTMKMFLF QFVNYYSSCF YVAFFKGKFV GYPGAYSYML GNLTKLRNEE CDPGGCLIEL
TTQLVIVMAG KQLWGNVQEA LLPLMRNWWS SRKGRHNPEN HYSRWEQDYV LQNFSQLGLF
YEYLEMVIQF GFITLFVASF PLAPLLALFN NILEIRVDAW KFTTQFRRPV ASKARNIGAW
QEILNAVAIL SVVTNAFIMA FTSDMIPRMV YLYVLSKDRS MSGYVNSSLS IYNISQIHPQ
NMPEERWYDN STTTCRYRDY RNPPGHQREY DHNMQFWHIL AAKMAFIIIM EHVVFVVKFF
VAWMIPDVPS DVKARIKRER YLIQEYLHNY EVERLKMQLS ASFITEPCSE MTLTSDKQEM
LSECL
//
