ID H2LQ60_ORYLA Unreviewed; 576 AA.
AC H2LQ60;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Solute carrier family 45 member 2 {ECO:0000313|Ensembl:ENSORLP00000008198.2};
GN Name=slc45a2 {ECO:0000313|Ensembl:ENSORLP00000008198.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008198.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008198.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008198.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008198.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008198.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC symporter transporter (TC 2.A.2) family.
CC {ECO:0000256|ARBA:ARBA00038193}.
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DR AlphaFoldDB; H2LQ60; -.
DR STRING; 8090.ENSORLP00000008198; -.
DR Ensembl; ENSORLT00000008199.2; ENSORLP00000008198.2; ENSORLG00000006533.2.
DR eggNOG; KOG0637; Eukaryota.
DR GeneTree; ENSGT00950000182914; -.
DR HOGENOM; CLU_015081_2_1_1; -.
DR InParanoid; H2LQ60; -.
DR TreeFam; TF325412; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000006533; Expressed in animal zygote and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008506; F:sucrose:proton symporter activity; IBA:GO_Central.
DR CDD; cd17313; MFS_SLC45_SUC; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR19432:SF34; MEMBRANE-ASSOCIATED TRANSPORTER PROTEIN; 1.
DR PANTHER; PTHR19432; SUGAR TRANSPORTER; 1.
DR Pfam; PF13347; MFS_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 576 AA; 63413 MW; 71A566BC4E556C5A CRC64;
MTLLSEDQSA RPQPCLLSEP DKHISTSLDQ YRPDYTKEDY MDSVETSVFG TVEPPRRSRG
RLILHSMVMF GREFCYAVEA AFVTPVLLSV GLPRSLYSLV WLISPILGFL LQPIIGSASD
YCRSSWGRRR PYILVLGILM LVGLSMFLNG DAVVSELVSD RSSRSTWAIV VVMFGVVLFD
FAADFIDGPI KAYLFDVCSY QDKERGLHYH ALFTGLGGAC GYLVGAMDWG HSVLGRLLGS
EYQVIYFFSA LTWGVFLIVH LFSIPEKPLA KVPSESSASS ALRLLGPHSN GYGALGKEPV
SPVIPTSSPE IRPRSYSAIG ERPRSFSALG EANSVTSSAK QPIKEDQKKM TFRSLMKAIF
NMPNHYRFLC ISHLLGWAAF LCNMLFFTDF MGQIVYRGNP YAEHNSTAYV TYERGVEVGC
WGLCINAVSS ALYSYVQRFL LPYIGLKGLY FMGYFVFGMG TSLIGLFPEV IATLILCSVF
GVMSSTLYTI PFNLIAEYQR EEEEQVKLQG GNECPRGTGM DCAALTCMVQ LAQIIVGAGL
GALVNAAGSV IVVVLSASSI SLIGCIFIAL FIRYVE
//
