ID H2LQ64_ORYLA Unreviewed; 477 AA.
AC H2LQ64;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit beta-3 {ECO:0000256|ARBA:ARBA00019004};
DE AltName: Full=Calcium channel voltage-dependent subunit beta 3 {ECO:0000256|ARBA:ARBA00030522};
GN Name=cacnb4.1 {ECO:0000313|Ensembl:ENSORLP00000008202.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008202.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008202.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008202.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008202.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008202.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2LQ64; -.
DR Ensembl; ENSORLT00000008203.2; ENSORLP00000008202.2; ENSORLG00000006530.2.
DR GeneTree; ENSGT00950000182837; -.
DR HOGENOM; CLU_021995_0_0_1; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000006530; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR008079; VDCC_L_b3su.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824:SF15; CALCIUM CHANNEL, VOLTAGE-DEPENDENT, BETA 4B SUBUNIT; 1.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR PRINTS; PR01696; LCACHANNELB3.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 57..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 14..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 53090 MW; 28B93E5513D73615 CRC64;
MYDNLYLHGF EDSEAGSADS YTSRPSDSDV SLEEEREVRQ EREQQAAVQL ERAKGKPVAF
AVRTNVSYCG ALDEDVPVPA TAISFDAKDF LHIKEKFNND WWIGRLVKEG CEIGFIPSPL
KLENIRLQQE QKRGRVQGKS GGNSSSSVED EVSASIRPLI SSSAVLCGQT EHVPPYDVVP
SMRPVVLVGP SLKGYEAAGR DAVLLLFLCR ITITRVTADI SLAKRSVLNN PSKRAIIERS
NTRSSLAEVQ SEIERIFELA RSLQLVVLDA DTINHPAQLL KTSLAPIIVH VKVSSPKVLQ
RLVKSRGKSQ SKHLNVQLVA ADKLAQCPPE MFDVILDENQ LEDACEHLAE YLEAYWKATH
TSLATPLNPL LGRNLGSTAL TPFSTSISGL QSQKLRQSNH AGDHATPNER RNLMAADENY
HNERAHKGRN RMSSGSQHSR EQQDPYQDYP DPYQDAYKPH RNRSSPGGYS HDSRHRL
//
