ID H2LQK4_ORYLA Unreviewed; 752 AA.
AC H2LQK4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Kirre like nephrin family adhesion molecule 3, like {ECO:0000313|Ensembl:ENSORLP00000008347.2};
GN Name=kirrel3l {ECO:0000313|Ensembl:ENSORLP00000008347.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008347.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008347.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008347.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008347.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008347.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; H2LQK4; -.
DR Ensembl; ENSORLT00000008348.2; ENSORLP00000008347.2; ENSORLG00000006651.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160603; -.
DR HOGENOM; CLU_013520_1_2_1; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000001038; Chromosome 16.
DR Bgee; ENSORLG00000006651; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd05759; IgI_2_KIRREL3-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 492..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 108..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 219..295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 304..384
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 388..484
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 539..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 81222 MW; FBC2E4E31647B3CA CRC64;
MGEKIVRAGG WQSTQAAYFS QQPQDQVVVS GQSVTLPCVI VGYRGMVQWT KDGLALGGER
DLPGWTRYSL MGDPLSGEHS LLIDSAELAD DAVYECQATQ AGLRSHRAKL TVLVPPSDPV
VEGGPVVRLK AHTPHNLTCR ASGAKPAAEI TWYRDGEVME TAIYSKTLMQ DGKRETAVSM
LPIIPEDSDT GRTYTCRVLN PAAPAGRQTS VTINVQHPPS VTLSVQPQTV TEGAKVLFLC
SASANPEITG YRWSKGGVPI SEANGDSLEV TVDYSYFTDP ISCEVSNSVG STNVSTLVDV
QFGPRLLSEP KPMTVDIGMD AAFTCAWTGN PPLTLAWTKQ GSSVVLSNGN TLQLKAVTQE
DAGTYTCKAI VPRIGVAERD VTLTVNGPPI ITADATQHAV KHSKGKLECR VGSSPPPDNI
VWTFGDMTLS SGSSGRYSVQ TVTSDRGVFS SLVLSETLAQ DFQMRYNCTA WNRFGTGTAL
VTLEEQEALP TLIIVGGAVG GGCVLLICVI TVVSLCCRHT GKGKRCTRLS KSDIRVQIVH
SDHNATRGND DEEDVKEPMA PNSSESPGTS RTEHSDLLEE EDDERSDIKD PTNGYYNVRG
HDDRNIRSGG FSEYVPNSRP VYTPSQLPSP SPVYGQHGTQ PRIYEFSQRY STNTVSRSSY
EQQQAGQQQP AQPASIYPTD PVYSSSAYLP ATYGRAFTSY VKPASYEKVD AYDQSDQASK
VSSSSRFSYA SSQVSSQQSD LGRPSQRMQT HV
//
