ID H2LR05_ORYLA Unreviewed; 849 AA.
AC H2LR05;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=atp6v0a2 {ECO:0000313|Ensembl:ENSORLP00000008502.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008502.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008502.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008502.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008502.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008502.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004072422.1; XM_004072374.2.
DR RefSeq; XP_011477460.1; XM_011479158.1.
DR STRING; 8090.ENSORLP00000032851; -.
DR Ensembl; ENSORLT00000008503.2; ENSORLP00000008502.2; ENSORLG00000006769.2.
DR Ensembl; ENSORLT00000039965.1; ENSORLP00000032851.1; ENSORLG00000006769.2.
DR GeneID; 101164234; -.
DR KEGG; ola:101164234; -.
DR CTD; 23545; -.
DR eggNOG; KOG2189; Eukaryota.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR OrthoDB; 1967517at2759; -.
DR TreeFam; TF300346; -.
DR Proteomes; UP000001038; Chromosome 18.
DR Bgee; ENSORLG00000006769; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 578..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 777..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 101..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 849 AA; 97657 MW; 145A7DFB9EBD77F3 CRC64;
MGSFLRGDEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPNVNAFQRK YVNEIKKCEE
MERILGYLLR EIKKADISLP DRDVNPVAPS PKNVMSIMEQ LQRFELELGE VTRNKERLQK
NLLELTEYTH MLRISRDFVQ RPIEREPLQT QYEEFPFLEK DTVMDYSSMQ RLGAKLGFFS
GLIQRAKIEA FERMLWRVCK GYTILSYAEV EEYLQDPDKG EAVKCVVFLI SYWGDQIGQK
VKKICDCYHC HLYPYPNSNE ERIDVMEGLK TRIQDLHTVL HRTEDYLKQV LVKASESVHS
WVVQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVSDIPT LRRSLEDGSK KSGSNISSFV
NRIPTTDTPP TLIRTNKFTS GFQNIVDAYG VGTYREVNPA PFTVITFPFL FAVMFGDLGH
GAIMALFAGW MVFYENNRKL KNTRNEIWNT FFEGRYIILM MGIFSIYTGL IYNDCFSKSL
NIFGSGWSVR PMFQTGEWTN DVLRGNHFLT LNPNIAGVFT GPYPLGIDPI WNLASNRLTF
LNSYKMKMSV IVGVIHMSFG VILSTYNHVY FKKKYNLYLV FLPELLFLLC LFGYLVFMIF
YKWLAFSAED SSNAPSILIH FINMFLMQGE EVQPLYTGQH GLQVFLVVIA VFSVPVLLLG
KPLYLYWLQH GRQHLGMYRG YERVRRSSDE ELYLLRTHDE EEGSSYSDLS GSGEKTTEQF
NLADEFLHQA IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWTMVMR VGLRMDTALG
VLFLVPVFGL FAVLTVSILL VMEGLSAFLH ALRLHWVEFQ NKFYSGTGVK FCPFSFSALP
SSFENDGLL
//
