ID H2LR29_ORYLA Unreviewed; 533 AA.
AC H2LR29;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
GN Name=relb {ECO:0000313|Ensembl:ENSORLP00000008526.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008526.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008526.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008526.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008526.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008526.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LR29; -.
DR STRING; 8090.ENSORLP00000008526; -.
DR Ensembl; ENSORLT00000008527.2; ENSORLP00000008526.2; ENSORLG00000006786.2.
DR eggNOG; ENOG502QV8A; Eukaryota.
DR GeneTree; ENSGT00940000160230; -.
DR HOGENOM; CLU_004343_3_0_1; -.
DR InParanoid; H2LR29; -.
DR TreeFam; TF325632; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000006786; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0038061; P:non-canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR PANTHER; PTHR24169:SF18; TRANSCRIPTION FACTOR RELB; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 84..264
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 59396 MW; 7F1C80176A340C05 CRC64;
TQRDSLPGPP PPPQDLHSQT VPSQSPRSVR QSARSNPVLV ARGMTADPSR EMTSPRSSRV
TSPPYPSATS SQNTSGTDLL EQILEKPRLV VVEEPKDRGM RFRYECEGRS AGSILGASST
DNHKTQPAIE IQGPIDRLKR VTVTVSLVTK DLPHRPHPHC LVGKDCPPGS GICVVSFNPH
NNRCHSFANL GIQCVRRKEL EVSLQKRRNQ NIDPFQTGHS KGIEDMDMNV VRLCFQCSLE
LDDGRKDMLS PVVSKPIYDK KATTTSELRI CHLNQYRGSC RGKTEIYMLC DKVQKDDIEI
IFRQGSWKAS GEFAQTDVHR QIAIVFKTPP YQDQDITGEV EVQLSLRRVS DQMESEPVTF
VYFPHNQDPY EVKRKRATIK RDIGFSERPC GTGEVLTSSL AAPPEEAVCT LLDNHSVLLP
EVPCGVDGSY SETQNSSSIL DETTLINQLL DMPEISQALS DPDFLSTLPC VFDPGLDTIS
ATMNHNFNPG FGPYPQDFAH FNDMQFNMLV NESQNSQVEA QDSSVQVKME EDL
//
