ID H2LR38_ORYLA Unreviewed; 1766 AA.
AC H2LR38;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ptprsa {ECO:0000313|Ensembl:ENSORLP00000008535.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008535.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008535.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008535.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008535.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008535.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSORLT00000008536.2; ENSORLP00000008535.2; ENSORLG00000006794.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_2_1; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000006794; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 7.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 26..116
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 128..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 314..404
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 409..503
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 507..599
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 604..706
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 711..810
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 811..909
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 910..1005
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1211..1466
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1386..1457
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1498..1757
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1675..1748
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 388..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1766 AA; 196972 MW; A6FDBDDDE6032191 CRC64;
HMCLAAPGDR FCISPLLCCF CLSAKPVFTK VPVDQTGVSG GVVSFVCHAT GDPKPKVSWS
KKGKKVNSQR IETIEFDEGA GAVLRIQPLR APRDENIYEC VAENSEGEIS VNARLAIIRE
DLLPPGFPNI DMGPQLKVVE RTRTATMLCA ASGNPDPEIT WYKDFLPIDP SASNGRIKQL
RSGALQIENS EETDQGKYEC VASNVEGVRY SSPANLYVRV RRVPPRFSIP PTSQEIMPGG
SVNITCVAVG SPMPYVKWML NSEDLTPEDE MPVGRNVLEL SSVRESANYT CVAMSSLGII
ESVAQITVKS LPKPPGTPVV TETTATSVTI TWDSGNPDPV SYYIIQYKAK SPDSKYETVD
DITTTRYSIG GLYPNTEYEI RVSAINTIGQ GPPSEPVETR TGEQAPASPP RNVNGQILPQ
NTMMVTWEEP EEPNGQIKGY RVYYTMDASQ PMSNWHIHNV QDSVITTIRS LTPLETYTIK
VLAFTSVGDG PFSPPIKVKV VQGVPGQPSK FQVGAVSDTS IELIWEPAHD KEAIRRYELR
YRESNHGNQV GILKTFDPTK SYVVESLRPN TEYYFSLAAI SDKGIGAFTN EILQKTLQAK
PSAPPQEIEC SSTSSTSLLV SWRPPPLKSQ NGDLTGYKVL YQVVSPSEGA GGDPQPTEEP
MIPPTEEQVL LQRLGKWTQY HITVSAATVV GLGPESEPII CRTDEDVPGA PPRRVEVDVL
NSTAIKVMWR SLTPGKQNGQ IRGYQVHYVR VENGESRGLP LIKDVMLADA QEMVIGGLKP
DTTYSITVAA YTTKGDGARS KPKLVVTKGA VPGPPYLSVA QNSKTSAVVH WDPPDLTNGM
DLQGYRLQFG RKDITPLATL EFAPQERRYS VDNIHRGATY LFKMAAKSRG GFGEEAVAEL
SVPENTPGGY PQIKEGSNVT CCSVLLSWSP PVLAERNGVI TEYTLVYKEA GTGEIPRELR
LHPSLSSYVL NSLKPNSAYE VKMRAHTSVG PGPYSPPIQY RTVAIHPAGR ACLFLSNPSG
RGLEQLLRVV PKHRSRRQLA QLDQRDAYIT ACFKQLPLSF IVGSDNRHNS CENKPLEPGQ
QHVFFLLAEL NKMFATSPYT DTVMSPELVV DLPAEHDETQ LWVVGPVLAV VFIICIVSAI
LLYKNHKRKE SEPRTKCLLN NADITPHHPT DPVEVRRINF QTPGMLNHPP IPISELAEHT
ELLKANDNLK LSQEYESIDP GQQFTWEHSN LEVNKPKNRY ANVIAYDHSR VILAPIEGIT
GSDYINANYI DGYRKQNAYI ATQGPLPETF GDFWRMVWEQ RAATVVMMTK LEEKSRIKCD
QYWPSRGTET YGMTQVTLLD TIELATFCVR TFSLHKNGSS EKREVRQFQF TAWPDHGVPE
YPTPFLAFLR RVKTCNPPDA GPIIAHCSAG VGRTGCFIVI DAMLERIKHE KTVDIYGHVT
LMRSQRNYMV QTEDQYSFIH DALLEAVACG NTEVAARSLY SYIQKLAQVE SGEHVTGMEL
EFKRLANSKA HTSRFISANL PCNKFKNRLV NIMPYETTRV CLQPIRGLEG SDYINASFID
GYRQQRAYIS TQGPLAETTE DFWRMLWENN STIVVMLTKL REMGREKCHQ YWPAERSARY
QYFVVDPMAE YNMPQYILRE FKVTDARDGQ SRTVRQFQFT DWPEQGVPKS GEGFIDFIGQ
VHKTKEQFGQ DGPISVHCSA GVGRTGVFIT LSIVLERMRY EGVVDIFQTV KMLRTQRPAM
VQTEDEYQFC YHAALEYLGS FDHYAT
//
