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Database: UniProt
Entry: H2LRA2_ORYLA
LinkDB: H2LRA2_ORYLA
Original site: H2LRA2_ORYLA 
ID   H2LRA2_ORYLA            Unreviewed;       800 AA.
AC   H2LRA2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=Disks large homolog 4 {ECO:0000313|Ensembl:ENSORLP00000008601.2};
GN   Name=LOC101159214 {ECO:0000313|Ensembl:ENSORLP00000008601.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008601.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000008601.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008601.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000008601.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008601.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_011481761.1; XM_011483459.1.
DR   AlphaFoldDB; H2LRA2; -.
DR   STRING; 8090.ENSORLP00000008601; -.
DR   Ensembl; ENSORLT00000008602.2; ENSORLP00000008601.2; ENSORLG00000006845.2.
DR   eggNOG; KOG0708; Eukaryota.
DR   GeneTree; ENSGT00940000157956; -.
DR   InParanoid; H2LRA2; -.
DR   OrthoDB; 2879721at2759; -.
DR   TreeFam; TF323171; -.
DR   Proteomes; UP000001038; Chromosome 14.
DR   Bgee; ENSORLG00000006845; Expressed in brain and 6 other cell types or tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0097113; P:AMPA glutamate receptor clustering; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR   GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          137..224
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          232..319
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          384..465
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          499..569
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          609..785
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          566..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..589
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  88596 MW;  D2E478ED8A7FC0E7 CRC64;
     MSLPVRNFKC LSPVMCQCKV ICSNRTLSLM FGCKKYRYQD EETPPLEHSP AHLAQGKSAE
     MLHMSDKNLA AMEAIHGYTP HTHISPVKPV LMSTGHTPMY TSAVSTLGNT PPVVVNTDTL
     DGSPYVNGTE GEIEYEEITL ERGNSGLGFS IAGGTDNPHV GDDPSIFITK IIPGGAAAQD
     GRLSVNDCIL FVNDVDVREV THSQAVEALK EAGAIVRLYV LRRKPAAEKV TEIKLIKGPK
     GLGFSIAGGV GNQHIPGDNS IYVTKIIEGG AAHKDGRLQI GDKILAVNNV CLEDVMHEDA
     VGALKNTAEV VYLRVAKPNN LFLTNSYNPP DLTSTYSHMD TELSHPGYLG SDYPQALTPT
     SPSRFSPVLH GMMGDDDIPR EPRRILIHRG STGLGFNIVG GEDGEGIFIS FILAGGPADL
     SGELHKGDQI LSVNGVDLRM ATHEQAAAAL KNAGQTVTIV AQYRPDEYSR FEAKIHDLRE
     QLMNSSMGSG TTTLRSNPKR GFYIRALFDY DKTADCGFLS QALSFRFGDV LHVLDCGDEE
     WWQARRVSPQ NEAEEVGFIP SKHRVERKDW SRGNTKERDH GRDSLSTQGR DKKMSQSYET
     VTQVEVHYAR PIIILGPVKD RINDDLLSEF PDKFGSCVPH TTRPKRDYEV DGRDYHFVSS
     REQMEKDIQS HRFIEAGQYN SHLYGTSVQS VREVAEQQGK HCILDVSANA VRRLQAAQLH
     PIAIFVRPKS LENVLEINTR LTEEQARKGM DRALKLEQDF LECFTAVVEG DSFEEVYHKV
     KTVVEEQSGP YIWIPTRERL
//
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