ID H2LRA2_ORYLA Unreviewed; 800 AA.
AC H2LRA2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Disks large homolog 4 {ECO:0000313|Ensembl:ENSORLP00000008601.2};
GN Name=LOC101159214 {ECO:0000313|Ensembl:ENSORLP00000008601.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008601.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008601.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008601.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008601.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008601.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_011481761.1; XM_011483459.1.
DR AlphaFoldDB; H2LRA2; -.
DR STRING; 8090.ENSORLP00000008601; -.
DR Ensembl; ENSORLT00000008602.2; ENSORLP00000008601.2; ENSORLG00000006845.2.
DR eggNOG; KOG0708; Eukaryota.
DR GeneTree; ENSGT00940000157956; -.
DR InParanoid; H2LRA2; -.
DR OrthoDB; 2879721at2759; -.
DR TreeFam; TF323171; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000006845; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0097113; P:AMPA glutamate receptor clustering; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 137..224
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 232..319
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 384..465
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 499..569
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 609..785
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 566..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 88596 MW; D2E478ED8A7FC0E7 CRC64;
MSLPVRNFKC LSPVMCQCKV ICSNRTLSLM FGCKKYRYQD EETPPLEHSP AHLAQGKSAE
MLHMSDKNLA AMEAIHGYTP HTHISPVKPV LMSTGHTPMY TSAVSTLGNT PPVVVNTDTL
DGSPYVNGTE GEIEYEEITL ERGNSGLGFS IAGGTDNPHV GDDPSIFITK IIPGGAAAQD
GRLSVNDCIL FVNDVDVREV THSQAVEALK EAGAIVRLYV LRRKPAAEKV TEIKLIKGPK
GLGFSIAGGV GNQHIPGDNS IYVTKIIEGG AAHKDGRLQI GDKILAVNNV CLEDVMHEDA
VGALKNTAEV VYLRVAKPNN LFLTNSYNPP DLTSTYSHMD TELSHPGYLG SDYPQALTPT
SPSRFSPVLH GMMGDDDIPR EPRRILIHRG STGLGFNIVG GEDGEGIFIS FILAGGPADL
SGELHKGDQI LSVNGVDLRM ATHEQAAAAL KNAGQTVTIV AQYRPDEYSR FEAKIHDLRE
QLMNSSMGSG TTTLRSNPKR GFYIRALFDY DKTADCGFLS QALSFRFGDV LHVLDCGDEE
WWQARRVSPQ NEAEEVGFIP SKHRVERKDW SRGNTKERDH GRDSLSTQGR DKKMSQSYET
VTQVEVHYAR PIIILGPVKD RINDDLLSEF PDKFGSCVPH TTRPKRDYEV DGRDYHFVSS
REQMEKDIQS HRFIEAGQYN SHLYGTSVQS VREVAEQQGK HCILDVSANA VRRLQAAQLH
PIAIFVRPKS LENVLEINTR LTEEQARKGM DRALKLEQDF LECFTAVVEG DSFEEVYHKV
KTVVEEQSGP YIWIPTRERL
//