ID H2LRP8_ORYLA Unreviewed; 761 AA.
AC H2LRP8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RUN and FYVE domain containing 1 {ECO:0008006|Google:ProtNLM};
GN Name=rufy1 {ECO:0000313|Ensembl:ENSORLP00000008749.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000008749.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000008749.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008749.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000008749.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000008749.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2LRP8; -.
DR STRING; 8090.ENSORLP00000008749; -.
DR Ensembl; ENSORLT00000008750.2; ENSORLP00000008749.2; ENSORLG00000006965.2.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000158334; -.
DR HOGENOM; CLU_014576_3_1_1; -.
DR InParanoid; H2LRP8; -.
DR TreeFam; TF323904; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000006965; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
DR CDD; cd15758; FYVE_RUFY1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047331; FYVE_RUFY1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956:SF4; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 192..324
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 695..753
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 123..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 375..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 86297 MW; 46C80C496F8F8F3F CRC64;
MWRHMVDFFV FCFVSEHRNN KVFPTFIPWP VTWYLSDKGG GGTNMADLAG NVNTACDDGV
ENQGEEPTVL DSEAFEELSD RAEQDAAGKS PSVAAENSWS APIFSLARKA SETISHGMSY
AAAPRKLSHG SSASSSNEKE SENDTSGSSK KILPVLPPKD PMGIERSNLL SMMKLSIKVL
IQSSLSLGRT LDSEYPPLQQ FFVVLEQCLK HGLKTKKSFI GQNKSIWGPL ELVEKLCPES
ANIATSARDL PGIRTGLGRG RAWLHLALMQ KKIADYIKAL LDHKDLLSEF YDSGAMMLEE
EGSVLGGLLV GLNVIDANLC IKGEDLDSQV GVIDFSLYLK DPASSETPKD DANMTAILDQ
KHYIEELNRH LSGTVTDLQA KLDSIEKTNS KLVEELTAAT DRINSLQDEQ EQLKKENESI
LQCSQKKEEA ALQDSQVELE TYKQTRQGLD EMYNVVWQQY KEEKRIRQEL QRELELQVGL
KQEMEVAMKL LEKDSHEKQD TLAALRLQLE QVKTLNLQMF HRAQESERQA EKKQEEAVKL
EQRMKDMEKA MEEMEQRLQN SECERKQSDQ SDEDMKVELE GKVDALQTQL TDLDTLRLGL
ENELRTEREQ RQSLQKALQR EQDNSSELRT QLQQLQGLHV ELQELKQEKQ QLQERCEQQE
QALQEMGLHL SQSKLKMEDF KEVNKALKGH AWLKDDEATQ CKQCQKEFSI ARRKHHCRNC
GDIYCNSCSS NELALPSYPR PVRVCDVCHA LLLQRSSSTA S
//
