ID H2LSL6_ORYLA Unreviewed; 1194 AA.
AC H2LSL6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Latent transforming growth factor beta binding protein 3 {ECO:0000313|Ensembl:ENSORLP00000009080.2};
GN Name=LTBP3 {ECO:0000313|Ensembl:ENSORLP00000009080.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009080.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009080.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009080.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009080.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009080.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H2LSL6; -.
DR Ensembl; ENSORLT00000009081.2; ENSORLP00000009080.2; ENSORLG00000007239.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160285; -.
DR HOGENOM; CLU_001884_1_0_1; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000007239; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF07645; EGF_CA; 12.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 14.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1194
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017478867"
FT DOMAIN 78..110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 214..257
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 290..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..387
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 468..509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 510..553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 637..677
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..718
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 719..758
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 759..801
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..865
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 929..969
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 975..1015
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1025..1078
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1145..1186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 193..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 82..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 100..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1194 AA; 132447 MW; B1BDA46C64AD623B CRC64;
MSSLIPRLLV IWLSVHRLVW CAERPSARER IKVVIAPLIC KRICLKGQCH DTCEQGNNTT
LIAENGQGAD TLIGQGFRVV VCPLTCMNGG VCSSRKHCLC PPGFTGQLCQ FPLQRSRQAQ
AARGNKQPVY SVPLKSDGPK LMEQSGLGRT QLAQTHSFFT LPFSQGGHHS SEVHVRVHHT
PDTSVVIHSL DQSDARSPHK IGPLPVPSRH KPKGRCFQET TPKQACNSTP LPVLTNQEDC
CGSVGNSWGQ NKCYQCPKLP NASVKHTIVE DYGSACPQGY KRYNSTHCQD INECSMQGVC
QNGDCLNTLG SFKCSCNSGF ILERNRCVDS PAEQAQCFLL ASESKGCEHP LSTQITQEMC
CCTVGKAWGR NCERCPHVGT VAFSKICPAG KGYLLQSITE TVALPPFFLP PKPPKEEQER
VPANTTPVQQ ISTSTSGPRV PVVKPTPPTI IRLNPGNDPL ETEIKVSQSD ECRLSRNICG
HGECENSPNG HICHCYPGYH LSPQRNICED ENECELEPCS QGRGRCVNTE GTYKCICSLG
FKHKVEHGGL RCKDIDECLK PDICGVGGLC VNLPGSYKCE CHSGFRSKSP RYPFCEDINE
CLNPDTCPNE QCENTLGSYE CTPCMPGYEA HAGKCYDINE CQNLGICPNG LCENLPGTYR
CLCLDGFLHS ADGKSCNDID ECADVRLCAN GRCINTDGSF QCQCYAGYQR TQEGSHCEDI
DECKRSSNCL RGRCINNMGS YHCECQRGYM LVGGKECQDI DECASDRNLC QPHGYCENRL
GSYVCICNHG YIPSEDKQSC EVVRVATDEK KECYMNLEDT VFCDSVLATN VTKQECCCSI
GMGWGDHCEI YPCPVSHSAE FHMLCPNGQG LYYDEDLHYS LPAYLDIDEC SLFAEEICKK
GRCHNTQPGY ECYCQQGFYY DSNLLVCIDV NECHDESLCA NGHCVNTEGS FYCDCNSPWI
PDTNKKKCVM ATVSDVDECQ DPSYCKNGRC ENTPGSFYCF CDPPLTFSAL LKQCVYDDRT
AAYKDVCFEQ VDEDLICSRP LQSLVVTYPE CCCHFGRGWG PECNTCPPRN SEMFNRLCEI
HLDTESDGEQ DFLAAFVNYK PGDSSEEDSD ECSCENGHCV RSYLSTMCKC NPGYRLDHSR
ARCIDIDECA ERAPRVSPCK NARCVNTSGS YKCYCNHGFG PTRRPNICVR RRTR
//