ID H2LSQ1_ORYLA Unreviewed; 456 AA.
AC H2LSQ1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Centrosomal protein 57 {ECO:0008006|Google:ProtNLM};
GN Name=LOC105355427 {ECO:0000313|Ensembl:ENSORLP00000009116.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009116.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009116.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009116.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009116.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009116.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR AlphaFoldDB; H2LSQ1; -.
DR STRING; 8090.ENSORLP00000009116; -.
DR Ensembl; ENSORLT00000009117.2; ENSORLP00000009116.2; ENSORLG00000007270.2.
DR eggNOG; ENOG502QTZR; Eukaryota.
DR GeneTree; ENSGT00530000063695; -.
DR HOGENOM; CLU_034321_2_0_1; -.
DR InParanoid; H2LSQ1; -.
DR TreeFam; TF329178; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000007270; Expressed in animal zygote and 10 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 52..230
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 326..397
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 148..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 115..142
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 174..215
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 340..394
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 456 AA; 51853 MW; D397956A42CD0E6D CRC64;
MPDSVSMSSY KDYPAHCPFV STLVHHTPQT RIQYSRCPAS PSKAFPETKR AAILSALRNL
QEKIRRLELD KGEGVLQVGE NDISHRVLPS ERVSQSLLND QIDTARREDS HSRSNQALIT
HLAAAESRCA KLERQLEYMR RMLRSDRAHG TRLHSQEFTK NPNAANKPAG MEKLEKLEEE
YLRLRCAQQN AETKILELEE KVQEEEHQRK LMQDRAKLIQ RGMEANRILL QSVSPALSKW
SKGKILISEE PSPRQVTHME PHYRLNLRDV PFVAGTSAGS SHSVRANVQA VLSLLKQHQP
HLCNRCVLLS NSNSCGTGFQ KRSDCSSSSC ASEEGLSELL QALQDELRLM SVEQDKLMLQ
LENNVSEEKR KELLKEQERL LLKMERKGEQ INKLYKYKSQ AKKLQKANSR RKSGNEVAIS
GRGRCVGTTK IPPGEGSRRN LRLLRDMKVL QASLRT
//
