GenomeNet

Database: UniProt
Entry: H2LST6_ORYLA
LinkDB: H2LST6_ORYLA
Original site: H2LST6_ORYLA 
ID   H2LST6_ORYLA            Unreviewed;      1928 AA.
AC   H2LST6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
GN   Name=MED13L {ECO:0000313|Ensembl:ENSORLP00000009152.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009152.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000009152.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009152.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000009152.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009152.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364134}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC       {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 8090.ENSORLP00000009152; -.
DR   Ensembl; ENSORLT00000009153.2; ENSORLP00000009152.2; ENSORLG00000007298.2.
DR   eggNOG; KOG3600; Eukaryota.
DR   GeneTree; ENSGT00390000013680; -.
DR   HOGENOM; CLU_000508_0_0_1; -.
DR   InParanoid; H2LST6; -.
DR   TreeFam; TF316867; -.
DR   Proteomes; UP000001038; Chromosome 12.
DR   Bgee; ENSORLG00000007298; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009401; Med13_C.
DR   InterPro; IPR041285; MID_MedPIWI.
DR   PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR   PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR   Pfam; PF06333; Med13_C; 1.
DR   Pfam; PF18296; MID_MedPIWI; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364134};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364134};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364134}.
FT   DOMAIN          1164..1486
FT                   /note="MID"
FT                   /evidence="ECO:0000259|Pfam:PF18296"
FT   DOMAIN          1522..1917
FT                   /note="Mediator complex subunit Med13 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06333"
FT   REGION          308..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          782..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1299..1353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..832
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1928 AA;  212843 MW;  9D6812FC5C2881D6 CRC64;
     HCSCCTLSGE HLLNCKSFTF ILNSNAELTG IKWRCYSFRS GGEFGPLISA PAQDDPVLRS
     FMRCVHANLL CVWRRKIKPD AKELWIFWWG EEPNLSDVIH HELEVAEEGL WECGLSYECR
     TLLFKAIHNL LERCLMDKGF VRIGKWFFKP HDLEEKSLGN SEHLSCCFSF FLHGESNVCT
     SVEIVQHQAA YHITDHHIRL AQTSTTPVQV VLSPYSLSGT LTGQAYKMSD PAVRKLIEEW
     SYFYPMVYPQ KEGSGEKEKG EAGQACDRCS HVAVEVIVGG VRMTYPAAFV LITQGDLPVE
     QPPVSVAQGL TKEPNNCSVP LTPPTSPEQP CSGKKKKKEN PDMNISPRKK QFSALTTELT
     QRKEAPNGVT TWNFNDLGSR TPCSCSRLKQ QKFNMAITSA TNTQTISSST QSSGPSLYPP
     SLPKHKTSDK TEKTDKQSKK PSVIPFHHRL TVTQDGPLEQ DSPGGPQMGG IVALDPPMET
     LASLPTCKYS KPMSNGRKPP ESLLHSPMSP LPPTLSPHPR MQDPEGLDVP LDATVCPDGG
     SGVGAITSET AVYTDLLRQR ENGVTLGLFE QPGVEVLREN GEDPYDFKEG DIEYTFSSSK
     RLKGPGREPS KKAKIKTFYF YNHFEICFYI IPHFPLSCLC VCLILAVADL QRMFPTPPSL
     EQHPAFSPIT PHRDTPSLEP PVPSGVADHL PPLASFQLAE CRMEMEESVA SPGQDDIKAY
     VFLSFQPQIC SSMFAPLSCL PSQNLPPSKI PDQCYYRPSW TLETFFDGTT ASVNTTILPS
     PAMPQFSVPT PRTPRTPRGI NAASSGQGSV KQDGTELSSP VSTPSTSLPL SSVEPLGRPG
     PSLPEAHSLY VVLLLSDSVL SVFKDRNFDS CCICACNMNV KGADVGVYIP DSTCEDQYRC
     MCGFSAIINR RLAHGTGLFL EDELDIFGRT SEVGQAAQRR LALCRRDPIM GDSRAKQPQE
     ATPASPSVMI VLQEQCSHPI SSLASLHLPL SCSCHGRKGA LLQSWMSEKQ WADESDACVE
     CYNALMQGLQ YVDNPTGGKV DLAVVRSSAL HSWPHTNVVD MSMLSSQDMV RMLLSLQPFL
     QDAIQKKRTG RTWENIQHVQ GPLTWQQFHK MAGRGSYGSE ESPEPLPIPT VLVGYDRERD
     FLALSPLALP FWEKLLLEPY GGQRDVAYIV LCPNSPSLLT AARSFFLELS AVYETCRLGK
     HRPLAKVSRD GLLQVGEDVE PEKLEDLDVD RWLTGPWAGQ QHTDNLLKLK LYAYTCKKQL
     GKKNPDTFLF CLFFCFYRLR TDIFLLCFRS PAVNPDFGQQ PSVASQSPVS GAVNASNAST
     PTGATGLTGE ATQAASSSSK GLPSATPSAN STAEHPEMLT SNLFFFSSCD QSRIGIPTLA
     DSVDSHINPP AVVIYIVDAF LSSAMTRNDG GEEEEGEEVE LTSIWLLGLL RCYTEMLRTL
     PEKIRPAVVL QVVPCQYLLQ PASGESHLYM QHLRSLAFSC YSQSRRLLRQ QTHIKSLTGF
     GPVSSVGSVL KSPEHPSPLQ LYSPPFILGP NRPKQPEPGE VWAELSPKYN VLFVGYCLSH
     DQRWILVSCT DQQGELLETC IINIDVPNRT RRPKVSPRKM GLQKLWDWCI GIIQMTSQPW
     RIVIGRLGRL GHGELKDWSS LLGEHSLHSI GRQLREACRM CGISAADSPS ILSACLVAME
     PQGSFVIMPD AVTMGSVFGR STALNLQTSQ LNTPQDASCT HILVFPTSAT TQLAASSYPT
     EDNNGNDMFD LPFPDELEND IGHDMMLITG NLHSSPNPSP VPSPGSLEMG SHFQHTRRLL
     SRDNPPEELK QQPLALGYYV STAQANGIPH WFWASCPQAE SQCPLFLKAS LHHHISIAQS
     EEIVSDKTKR APHPLDSKTT SDVLRFVLEQ YNALSWLTCT PATQDRQSCL PVHLAVLIQM
     YNAILNML
//
DBGET integrated database retrieval system