ID H2LST6_ORYLA Unreviewed; 1928 AA.
AC H2LST6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
GN Name=MED13L {ECO:0000313|Ensembl:ENSORLP00000009152.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009152.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009152.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009152.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009152.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009152.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR STRING; 8090.ENSORLP00000009152; -.
DR Ensembl; ENSORLT00000009153.2; ENSORLP00000009152.2; ENSORLG00000007298.2.
DR eggNOG; KOG3600; Eukaryota.
DR GeneTree; ENSGT00390000013680; -.
DR HOGENOM; CLU_000508_0_0_1; -.
DR InParanoid; H2LST6; -.
DR TreeFam; TF316867; -.
DR Proteomes; UP000001038; Chromosome 12.
DR Bgee; ENSORLG00000007298; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1164..1486
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1522..1917
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 308..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1928 AA; 212843 MW; 9D6812FC5C2881D6 CRC64;
HCSCCTLSGE HLLNCKSFTF ILNSNAELTG IKWRCYSFRS GGEFGPLISA PAQDDPVLRS
FMRCVHANLL CVWRRKIKPD AKELWIFWWG EEPNLSDVIH HELEVAEEGL WECGLSYECR
TLLFKAIHNL LERCLMDKGF VRIGKWFFKP HDLEEKSLGN SEHLSCCFSF FLHGESNVCT
SVEIVQHQAA YHITDHHIRL AQTSTTPVQV VLSPYSLSGT LTGQAYKMSD PAVRKLIEEW
SYFYPMVYPQ KEGSGEKEKG EAGQACDRCS HVAVEVIVGG VRMTYPAAFV LITQGDLPVE
QPPVSVAQGL TKEPNNCSVP LTPPTSPEQP CSGKKKKKEN PDMNISPRKK QFSALTTELT
QRKEAPNGVT TWNFNDLGSR TPCSCSRLKQ QKFNMAITSA TNTQTISSST QSSGPSLYPP
SLPKHKTSDK TEKTDKQSKK PSVIPFHHRL TVTQDGPLEQ DSPGGPQMGG IVALDPPMET
LASLPTCKYS KPMSNGRKPP ESLLHSPMSP LPPTLSPHPR MQDPEGLDVP LDATVCPDGG
SGVGAITSET AVYTDLLRQR ENGVTLGLFE QPGVEVLREN GEDPYDFKEG DIEYTFSSSK
RLKGPGREPS KKAKIKTFYF YNHFEICFYI IPHFPLSCLC VCLILAVADL QRMFPTPPSL
EQHPAFSPIT PHRDTPSLEP PVPSGVADHL PPLASFQLAE CRMEMEESVA SPGQDDIKAY
VFLSFQPQIC SSMFAPLSCL PSQNLPPSKI PDQCYYRPSW TLETFFDGTT ASVNTTILPS
PAMPQFSVPT PRTPRTPRGI NAASSGQGSV KQDGTELSSP VSTPSTSLPL SSVEPLGRPG
PSLPEAHSLY VVLLLSDSVL SVFKDRNFDS CCICACNMNV KGADVGVYIP DSTCEDQYRC
MCGFSAIINR RLAHGTGLFL EDELDIFGRT SEVGQAAQRR LALCRRDPIM GDSRAKQPQE
ATPASPSVMI VLQEQCSHPI SSLASLHLPL SCSCHGRKGA LLQSWMSEKQ WADESDACVE
CYNALMQGLQ YVDNPTGGKV DLAVVRSSAL HSWPHTNVVD MSMLSSQDMV RMLLSLQPFL
QDAIQKKRTG RTWENIQHVQ GPLTWQQFHK MAGRGSYGSE ESPEPLPIPT VLVGYDRERD
FLALSPLALP FWEKLLLEPY GGQRDVAYIV LCPNSPSLLT AARSFFLELS AVYETCRLGK
HRPLAKVSRD GLLQVGEDVE PEKLEDLDVD RWLTGPWAGQ QHTDNLLKLK LYAYTCKKQL
GKKNPDTFLF CLFFCFYRLR TDIFLLCFRS PAVNPDFGQQ PSVASQSPVS GAVNASNAST
PTGATGLTGE ATQAASSSSK GLPSATPSAN STAEHPEMLT SNLFFFSSCD QSRIGIPTLA
DSVDSHINPP AVVIYIVDAF LSSAMTRNDG GEEEEGEEVE LTSIWLLGLL RCYTEMLRTL
PEKIRPAVVL QVVPCQYLLQ PASGESHLYM QHLRSLAFSC YSQSRRLLRQ QTHIKSLTGF
GPVSSVGSVL KSPEHPSPLQ LYSPPFILGP NRPKQPEPGE VWAELSPKYN VLFVGYCLSH
DQRWILVSCT DQQGELLETC IINIDVPNRT RRPKVSPRKM GLQKLWDWCI GIIQMTSQPW
RIVIGRLGRL GHGELKDWSS LLGEHSLHSI GRQLREACRM CGISAADSPS ILSACLVAME
PQGSFVIMPD AVTMGSVFGR STALNLQTSQ LNTPQDASCT HILVFPTSAT TQLAASSYPT
EDNNGNDMFD LPFPDELEND IGHDMMLITG NLHSSPNPSP VPSPGSLEMG SHFQHTRRLL
SRDNPPEELK QQPLALGYYV STAQANGIPH WFWASCPQAE SQCPLFLKAS LHHHISIAQS
EEIVSDKTKR APHPLDSKTT SDVLRFVLEQ YNALSWLTCT PATQDRQSCL PVHLAVLIQM
YNAILNML
//