ID H2LTQ2_ORYLA Unreviewed; 1351 AA.
AC H2LTQ2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN Name=phldb1a {ECO:0000313|Ensembl:ENSORLP00000009472.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009472.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009472.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009472.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009472.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009472.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSORLT00000009473.2; ENSORLP00000009472.2; ENSORLG00000007557.2.
DR eggNOG; ENOG502QPZY; Eukaryota.
DR GeneTree; ENSGT00940000155231; -.
DR HOGENOM; CLU_003180_0_0_1; -.
DR TreeFam; TF329165; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000007557; Expressed in bone element and 10 other cell types or tissues.
DR CDD; cd22713; FHA_PHLB1; 1.
DR CDD; cd14673; PH_PHLDB1_2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037810; PHLDB1/2/3_PH.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12156:SF31; PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1 ISOFORM X1; 1.
DR PANTHER; PTHR12156; PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 1241..1344
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 590..746
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1126..1192
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 211..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1351 AA; 151635 MW; 92D41367A24C208D CRC64;
MDRLSGNKHE RQTHQVLQNT PLDLIETGKS LKVQAERPHL VSLGSGRLST AITLLPLLEG
RTTLGSERTD IPLHGPGIAP QHCYIENQAG SITLYPCGNP CSVDGLAISK PYRLTQGCML
CFGQSAFFRF NHPEEAQRMK NMLPGGHLDA PKTLTSDTHR SSNGNHELFS SDATLNNMAK
NLQNSLVLKA SASLGTGKQH GQAAPADLHL NGKNGSSTTA ENKSISLGQN SSDKPFPVAT
RSMNTSQIPV PHPRTSRSTA LSDTSVGQKI HESPKPLRKS RAEATPSPKP HIKGLGQGPE
NLSFIPSHTA PSTKFSTAPP SPRLRDSYLQ RRSHSPMQHH VDVLQKPTGS NTLKELPPPS
PHMSCRETQR SPQSQRKHAS PSKTEHMRSP HIRTPSSLTK AGSEFGSRAM RPEPGSALTP
SLGSGPGLSP LASPRSQRKT SAVSTRASGN KEGNLTKPYS RERKNSISEI SDNEDELLEY
HRWQREERLR EQEMEKLERQ RLETILNLCA EYNQEDRSAE LVRTGLLEVF RGVTSDAAER
TSHQGEGRAQ RLRDNDEDLQ REESSSTEST HQEHEDMFTG QEQAYLEEER SKILARVDGL
KHKVSELEQQ LQETKQEVEM EQALLQAERW AEQEEVEAEN QIISQLELRL GQLNKAAQQE
KDKGRANVSA ERSLLEKQRN EYNELKRQFD KCPLSEREQL QEQLSRKAEA IESGTKQFEE
LEFCQLEEES RLEERKEAQS SQLLREQTEF HYSVANRKEK VAALDAQVRQ LGLQASQDCE
RMVKERTAAL QQLQKEQDRL CSLERRYQAL TGEEQFPKAT SSVKEESLHI SETDLVNVDG
PLHSPCPSSA SSSSIIPSPE LCPVRLQEEY LRLSDVYRMY GNASMQPLPS SLAALHCLSL
SAPPALPCEE YITVSQLSQI FGMQRVIPSS SSSTPSFQLA SSESSFSSRS AAYGPSSFLS
TQSQAELSRN VMTPINLERW YQDIMAAGEP QSCPPPLPAK SFSTRRHGQL LKSKSEGEVG
QGSSGSHVAG AVVMSHSSSL MNERNSATKG LQLMLRETSN PLDMDSRRQM ASLFKDPSPS
VNHSILHHQP PPSGSQAYDT LSLESSDSLE TSVSTGNSAC TPESACGAEA QRMEEMEKLL
KEAQQEKARL IENREREVQS RRQMLEEERR RREEAERRLQ DEAAHRQRLV EEEVKMREKH
FSQARPMTRY LPNRKEEFDL RAHVESCGHS LDTCPFVILT EKMCKGHLVK MGGKIKSWKK
RWFVFDRLKR NFCYYVDKHE TKLKGLIYFQ AIEEVYYDHL RSATKSPNPS LTFCVKTHDR
LYYMVAPSPE AMRIWMDVIV TGAEGYTQFM S
//