ID H2LU74_ORYLA Unreviewed; 491 AA.
AC H2LU74;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN Name=fscn2a {ECO:0000313|Ensembl:ENSORLP00000009648.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000009648.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000009648.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009648.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000009648.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000009648.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR RefSeq; XP_004071455.1; XM_004071407.2.
DR AlphaFoldDB; H2LU74; -.
DR STRING; 8090.ENSORLP00000009648; -.
DR Ensembl; ENSORLT00000009649.2; ENSORLP00000009648.2; ENSORLG00000007705.2.
DR GeneID; 101170272; -.
DR KEGG; ola:101170272; -.
DR CTD; 798075; -.
DR eggNOG; ENOG502QPRX; Eukaryota.
DR GeneTree; ENSGT00950000183157; -.
DR HOGENOM; CLU_030960_2_0_1; -.
DR InParanoid; H2LU74; -.
DR OrthoDB; 5484756at2759; -.
DR TreeFam; TF323992; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000007705; Expressed in sexually immature organism and 2 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF24; FASCIN-2; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 21..132
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 143..253
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 265..374
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 389..491
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 491 AA; 54656 MW; F9B8E7BAA751ABA7 CRC64;
MPTNGINQAL KLQFGLINYE NRYLTAEAFG FKVNASGTSM KKKQIWTLEQ DEQDGQVVFL
RSHLGRYLAA DKDGKITCGA EKPDPECRFL IVPQSDGRWA LQSEPYLRYF GGSADYLSCF
AQVIGEQELW AVHLALHPQA SLLSVARKRY AHLSASDGEI SVDSNIPWGV DSLVTLVYLD
GKYSLKTCDS RFLSNDGKLV KENSNTTCFT LELKSGKLAF KDCDGKYLAP LGPTGTLRSG
RCSKPGKDEL FDLEESHPQV VFQAANKRFV SVKQGVSISA NQDVETDMET FQMEIDKESK
KALFRTNGGS YWTLVTHGEI QSTAKEVEIN TMFDIEWRGQ RVALKASNGK YVCTKKNGQL
SAISETVGDD ELFLMKLINR PMLILRGENG FVCHHKNSNT LDANRSVYDI FSLIFNDGAY
IIKSVNGKFW YVSSNGLVCS DGEKSENFFL EFLEHGRVAI KGSNGKYLRG DQGGTLMCDG
ASVDVSSLWE Y
//
