ID H2LV75_ORYLA Unreviewed; 704 AA.
AC H2LV75;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Amyloid beta precursor protein binding family A member 3 {ECO:0000313|Ensembl:ENSORLP00000010005.2};
GN Name=APBA3 {ECO:0000313|Ensembl:ENSORLP00000010005.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010005.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010005.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010005.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010005.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010005.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004068023.1; XM_004067975.2.
DR RefSeq; XP_011472313.1; XM_011474011.1.
DR RefSeq; XP_011472314.1; XM_011474012.1.
DR AlphaFoldDB; H2LV75; -.
DR STRING; 8090.ENSORLP00000010005; -.
DR Ensembl; ENSORLT00000010006.2; ENSORLP00000010005.2; ENSORLG00000007976.2.
DR GeneID; 101162033; -.
DR KEGG; ola:101162033; -.
DR eggNOG; KOG3605; Eukaryota.
DR GeneTree; ENSGT00940000160384; -.
DR InParanoid; H2LV75; -.
DR OrthoDB; 2881953at2759; -.
DR TreeFam; TF315245; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000007976; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF9; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 341..485
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 523..608
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 613..690
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77421 MW; DA422888D1CFAA24 CRC64;
MDSRHHPVNQ YTTCAEGLEA DSIPAHGISE REESATASRP PEAEDLDCYS MMEPPPLDWR
SDSSSEAGSP EDLVDSTLPQ SACSLGIEDL GESGCQPMDA GRKMTSFDPK TDFFLGNTAG
SVQNIEVKLE KELQEEVAAE VVEDQEEMTS RDAEKKVDND KTHVLSRRPD DEDHNHIHTL
LSHLQLREKD SHTSHQSSFQ PEPGARTSFR RREDGAESKG LLFSESHHTD LLGLLQCTEI
NAESRSVYRS HRGEVDAVVS VSYSQEDAQR FWGLHGSSQH PQHRDDSISP LSDYNYPEPV
WKKMGEEPPE DEVEAESKQS SDDRPSYKDV PGPCDPEDLL DGVIFGAKYL GSTQIKSDRN
PSTNARMAQA HEAVDRIKAP EGESQPMTEV DLFISTQRIK VLTADTQEAM MDHALQMISY
IADIGKIVVL MARRKQKGHE GDSASTGSQK KCTMICHVFS SEDAQIIAQA IGQAFGVAYQ
QFLQASGIKA SDLRPGEYSD YLETQELYNG DLAHFSDSQN LRDVVITKAP GEILGLAVVE
SGWGSILPTV VVANLLHGGP AERCGELSIG DRIMSVNGTS LVGLPITTCQ NIIRDLKSQK
YVKLSIVHCP PVTMAIIRRP DPKFQLGFSV EDGIICSLMR GGIAERGGIR VGHRIIEING
QSVVATPHEK IIQTLTNAVG EIHLKTMPAS TYRLLTGQEQ PVFL
//
