ID H2LVW4_ORYLA Unreviewed; 960 AA.
AC H2LVW4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=SAFB-like, transcription modulator {ECO:0000313|Ensembl:ENSORLP00000010249.2};
GN Name=sltm {ECO:0000313|Ensembl:ENSORLP00000010249.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010249.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010249.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010249.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010249.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010249.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004067223.1; XM_004067175.2.
DR AlphaFoldDB; H2LVW4; -.
DR STRING; 8090.ENSORLP00000010249; -.
DR Ensembl; ENSORLT00000010250.2; ENSORLP00000010249.2; ENSORLG00000008161.2.
DR GeneID; 101161618; -.
DR KEGG; ola:101161618; -.
DR CTD; 79811; -.
DR eggNOG; KOG4661; Eukaryota.
DR GeneTree; ENSGT00940000156573; -.
DR HOGENOM; CLU_011145_1_0_1; -.
DR InParanoid; H2LVW4; -.
DR OrthoDB; 5405075at2759; -.
DR TreeFam; TF325240; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000008161; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0050684; P:regulation of mRNA processing; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR15683:SF5; SAFB-LIKE TRANSCRIPTION MODULATOR; 1.
DR PANTHER; PTHR15683; SCAFFOLD ATTACHMENT FACTOR B-RELATED; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 13..47
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 312..390
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 49..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..169
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 108864 MW; 35B2F0E718C95B3A CRC64;
MASGAISTGF KKISELRVVD LKSELKRRNL DTIGVKSILL ARLKKAIEDE GGDPENIQIQ
LSTDSTTRKS GKFKGKKTDS DVETTTEEDS YVKENEECES EKDVTDTDDG TRENSKPPPC
GESLACSEAE PETEAIAPED DSEPEPEAEV EPGDEDAEAE AEAESEVPEL DAEAMSSSKD
AEDDHLFVSM QNEDAITLDV DGDDLLDTGK HVKLLDPEAE KSIDEPEASA DTYPDDDMKD
KELEGPEDGK DEDESGDKTT KKAETGDKDK DSGNKGPSTS GASGQEKSSS RDRDGKAAKD
EKAAGSNSSS SQNLWVSGLS SNTKAADLKN LFGKYGKVLS AKVVTNARSP GSKCYGLVTM
SSSTEVTRCI THLDCTELHG QEIYVKRAKN DPFKKGPSKN EEEDKASSSK LSDKRISAGT
KMVNKAQSSN KKAEKKPEKS LEKDKDLSKK QEARSGRSES VSSNSDQDSL KKDDRKHGRS
ISPGKVMMVD HNRGDPNFRP RPFRRGRYFD QPFPNPNFQR QPRWLIPPEE LEIIRQKRRQ
FSNKDEVAEI LPFEKIKEQR EQRIRERMER ARRAVDLRRR REMAEQERRE RERVRLLRES
EEHENLLRER QRLEMERQKL ERERLERERL ERERIRIEQE RRKEAERMAR EREELRRQQE
QLRFEEKRNN FKRGREPEHG RREGPFWNGN KKIQQESEVR SNQGSNFNRP QNRFPNFNPR
ERGRFPEAAA AQQPNTFDRR NRFDGEPEMK KSRPAPLREG AAFDRYPKNF DAIRRPVPPT
RGDVRDTDRR DRDDRRPAPM HDRPVGPRAP LPTMSHTRTA RVGGHGPWKN EGLTTKGDMR
APIRVHSERA GPSVNRGRSN FNDREEGRPV MISNQTFGSG RQVVVERHGR EQGLRKDWHG
SSSSQAGGFT DNRRIVDSRG SVMTSSHSSG IGRIVQITNS NPSGGAVGGF KPFKGVPRPF
//
