ID H2LWQ8_ORYLA Unreviewed; 443 AA.
AC H2LWQ8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Neurofilament heavy chain {ECO:0000313|Ensembl:ENSORLP00000010550.2};
GN Name=NEFH {ECO:0000313|Ensembl:ENSORLP00000010550.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010550.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010550.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010550.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010550.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010550.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; H2LWQ8; -.
DR Ensembl; ENSORLT00000010551.2; ENSORLP00000010550.2; ENSORLG00000008401.2.
DR eggNOG; ENOG502QYDU; Eukaryota.
DR GeneTree; ENSGT00940000161893; -.
DR HOGENOM; CLU_428718_0_0_1; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000008401; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 58..369
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..166
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 260..333
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 50948 MW; 7BFDCC59432609C2 CRC64;
MSFMVDHHNM GPSSYRKARP ASVSSSGFHS QRRRLTYSQP SSIDSLETFN GDMTRRSEKE
ILQALNDRFA GYIDKVRNLE MHNRNLEAEA AALRQSQAGR TSVGEHYERE LGDLRGLLQQ
LTGEKARAVM EHDHLEEDIQ HLRGRLEDEA RNRDELEAAA RAMKKYAEDC RLARMELDKK
LCALEEEADF LKKNHEEEVA DLLAQIQGAQ VSFDMRDALK ADVTSALREI RAQLDSHASK
SATHPEDWYQ VRMERLSDAA KSNQDAIRGS QEEIAEYRRQ LQSRIIELET LRGTKESLER
QRMESEDRHQ DDINSLQETI NQLDSELKNT KWEMASQLRD YQELLNVKMA LDIEIAAYRK
LLEGEENRVV SGGSPYSYLD SRLSGHMKLV LKHVHLTLHC LQSGVCRKGS NRKQIHTLRL
SSVRPEHSPF QLRERKKSGE ISG
//
