ID H2LX21_ORYLA Unreviewed; 1012 AA.
AC H2LX21;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Synemin, intermediate filament protein {ECO:0000313|Ensembl:ENSORLP00000010669.2};
GN Name=synm {ECO:0000313|Ensembl:ENSORLP00000010669.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010669.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010669.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010669.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010669.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010669.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004070079.1; XM_004070031.2.
DR AlphaFoldDB; H2LX21; -.
DR STRING; 8090.ENSORLP00000010669; -.
DR Ensembl; ENSORLT00000010670.2; ENSORLP00000010669.2; ENSORLG00000008497.2.
DR GeneID; 101161634; -.
DR KEGG; ola:101161634; -.
DR CTD; 23336; -.
DR eggNOG; ENOG502QTUH; Eukaryota.
DR GeneTree; ENSGT00940000159268; -.
DR HOGENOM; CLU_878646_0_0_1; -.
DR InParanoid; H2LX21; -.
DR OrthoDB; 5353519at2759; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000008497; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0043034; C:costamere; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR GO; GO:0060053; C:neurofilament cytoskeleton; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR GO; GO:0019215; F:intermediate filament binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0008307; F:structural constituent of muscle; IBA:GO_Central.
DR GO; GO:0017166; F:vinculin binding; IBA:GO_Central.
DR GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IBA:GO_Central.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR030634; SYNM.
DR PANTHER; PTHR47136; SYNEMIN; 1.
DR PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 11..319
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 411..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..83
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 119..146
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 196..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 427..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 114720 MW; 03AA5C4FAB58E33C CRC64;
MLPFKRTFDS EKQQLQELNS RLAQYLSRTQ QLEQENALLI TEISHLKQVK KTPEWQQNYR
AEMHDLRRMV EQLSFEKSQA ELEREKLWRE LQTVQSACSE QTEACRDMSG ELQSCAQELQ
QSHKINGELQ QRLLQLQDEC KRLEEAHRRD VHHLHRQVDS RVAPFLTQTH RGAPVVSVEE
VQKYARGLSE GWIETFEMYQ RKVEEMERAI QEDQARLSDM KTEKMMYSSE LGKLRTETQR
QAQTQRRLEE QLMAMQQKFQ LEFNEHQMII EQLEHERNSL ADAMAEKMRE HQHLLQVKMD
LGMEVAAYRA LLENEKNGLQ DAHKRINRPQ RERIIDIKVP AQTYSPRTSL LTSSQRTDIK
YTSPMNLRRS PKVPSGSVSP PRVVPFSLVG KARHQSPASR RDMISFNKAQ AAASIPSAPP
TLTVKDKQTG RIEKEENRNV QKTAGEQETG IFKPDSEDKR ISHTAETKSV RVVSAPAIIL
GAKKEAESKK QVLEKNERGS VHDTFREKDQ AETATGPTEK KILDAVSVEE IIEKVIKPAG
LEAKVCSSGD SKVTYHVEKS EEDDGRTKTQ IVLESKVEEE LDISADSALE ELLSHGVKKV
SLESMDDTAT ASMIKSLISS IQGGQNLQNR SVNVEIIEEP MESYSDEEAA VEQKSKPSFY
EPSTYFQIEE LEHVPHDVRE ERLSDDGTKS SFSTTDWSSG RSVQAHEVPR EDGSPHFSHV
QEYFVSTPDE NFSEPEGGGI TSYGHYGVVD DLSDERYYQD ESIPQRRVIV EESDESKYMS
GDGSFGKESF PECIIEEEVR VSPEVQESFL EFLREESLEP KEQLKGALEK LQTSVSGPLR
EELAFLTKVS SESPQNVAIK KVEQSADNGT VTVVAELNVS QTLEDSGLLD SEDVSEEQIM
AALRSSNLAL EKSLGGGAGG GYSIKVFEES EHVGGDDFKG FSEERKLTSE MIEKHVKLGL
PEKSFTFQMD VESSCAETSS DKELQFETME TPEKISHEKK VATLYLEGPS EN
//
