ID H2LXY6_ORYLA Unreviewed; 564 AA.
AC H2LXY6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000010998.2};
GN Name=ocel1 {ECO:0000313|Ensembl:ENSORLP00000010998.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000010998.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000010998.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010998.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000010998.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000010998.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR RefSeq; XP_004078998.1; XM_004078950.2.
DR AlphaFoldDB; H2LXY6; -.
DR STRING; 8090.ENSORLP00000010998; -.
DR Ensembl; ENSORLT00000010999.2; ENSORLP00000010998.2; ENSORLG00000008759.2.
DR GeneID; 101163767; -.
DR KEGG; ola:101163767; -.
DR CTD; 563081; -.
DR eggNOG; KOG4796; Eukaryota.
DR GeneTree; ENSGT00940000166235; -.
DR HOGENOM; CLU_039176_0_1_1; -.
DR InParanoid; H2LXY6; -.
DR OrthoDB; 5360956at2759; -.
DR TreeFam; TF337682; -.
DR Proteomes; UP000001038; Chromosome 17.
DR Bgee; ENSORLG00000008759; Expressed in intestine and 7 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR Gene3D; 6.10.140.340; -; 1.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR010844; Occludin_ELL.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR PANTHER; PTHR23288:SF37; SI:DKEY-208K22.6; 1.
DR Pfam; PF01284; MARVEL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR PROSITE; PS51225; MARVEL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 193..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..364
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT DOMAIN 441..552
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 64321 MW; E2C7D7BE284EBFA5 CRC64;
MSSKNTKFNR QEDGSEIRSS SPRRTSFSDP AVPVWVTHAP TPDNLTDPSD GDSNSTSQTQ
SVSPCDKKKS SKMGGMTRRL KSFVPHSWGV LSRKSEKQSH PERSKTVIQD LPNGTRVSPP
VSPLLKPRNL DESLASSSQS SRKPLLKESL LEDPFFLSLQ EDSLLTSIHP AEYYAEKLEV
YNMKYSYLKS WPGLLRLLGG LQLLFGGMVF ACVIAYIQKD SEWSNTYGQY NGVINNGFGP
SAYSYGGPMT PFILAVAGLS WILTLCLLVV GITMYYRTIL LDSSWWPLTE AFLNIALFLL
YMAAGIVYLN DLNRGGLCYM TIGVNPIMSK LCRVEGGQMA GTAFIFINMT MYLGSFLVCL
KMWRHEATRK ERKRSDTKGD FQHSIPLTTQ TKHISFTDEP DEALNKQNSF PSEPSSEVQK
NSVSWSRTAK STHEPRVHVI ADYILKYPVI RCVEERDEYR AVFNDQYQEY KELHCDITAT
LNKFRELDAI MERLPKQRKN LMDQERIESI LKKYHEKKND PTFLEKKERC YYLKAKLSHI
KTRIQTFDKE TAVNTDLKHS RTTK
//
