ID H2LYL2_ORYLA Unreviewed; 527 AA.
AC H2LYL2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Zgc:109965 {ECO:0000313|Ensembl:ENSORLP00000011231.2};
GN Name=zgc:109965 {ECO:0000313|Ensembl:ENSORLP00000011231.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011231.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011231.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011231.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011231.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011231.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR AlphaFoldDB; H2LYL2; -.
DR STRING; 8090.ENSORLP00000011231; -.
DR Ensembl; ENSORLT00000011232.2; ENSORLP00000011231.2; ENSORLG00000008956.2.
DR eggNOG; KOG2526; Eukaryota.
DR GeneTree; ENSGT00500000044945; -.
DR HOGENOM; CLU_034102_2_0_1; -.
DR InParanoid; H2LYL2; -.
DR TreeFam; TF105849; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000008956; Expressed in sexually immature organism and 3 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR CDD; cd03882; M28_nicalin_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF3; NICALIN-1-LIKE; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR PIRSF; PIRSF011018; Nicalin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..527
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017377374"
SQ SEQUENCE 527 AA; 59149 MW; 6C00AF8C108FDA14 CRC64;
MLLRSVVVLL VLSVQHLHGS ALPAVSSYEF TAFRMQQYNL GQQKHGCRGA IVVAEARSAD
EPSLTRRCII MKVEDFSAEK YLEAQGQNAA AVLILLPKNI SSVPHSTVQT FMMSESVALQ
KETLIPVYVA PEDEQLLYMY EEVKQAAAAR TSSIFVRVLR SIVTATAFQI LVSNNAPIKA
ITDNAIVTLE GVLPGAGEDA PTIVITAYYD SYGLAPWLSF GADSNGSSVT ILLELARLFQ
KLYSSSSTRP YNLMFSLTGG GKYNFLGTKR WIEENLDHAE SSLLHDNVAF VVCLDTLGKS
DELFVHVSRP PKPDTPVHSF IQQLEEVVSS RFSWVKVGLV HKKINLVEST IAWEHERYSL
RRIPGFTLSH LEDPKSALRG SILDTMSQVD FRKLKRNGLI IAETLARFMY NLTDKGSPKD
VQVFKGQLDF QDSRLSSLMS FLTSVPRATQ LLDKEQSQIL MVNSLEHEFK RYLQQVHRHT
FRQDRRDPDV SFFDQMNQPI VMYSGEFPDV FGDCLLFNPA SVKSKHQ
//
