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Database: UniProt
Entry: H2LYS0_ORYLA
LinkDB: H2LYS0_ORYLA
Original site: H2LYS0_ORYLA 
ID   H2LYS0_ORYLA            Unreviewed;      1184 AA.
AC   H2LYS0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   05-JUN-2019, entry version 53.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSORLP00000011290};
GN   Name=LOC101172200 {ECO:0000313|Ensembl:ENSORLP00000011290};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011290, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000011290}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011290};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000011290}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011290};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   STRING; 8090.ENSORLP00000011290; -.
DR   Ensembl; ENSORLT00000011291; ENSORLP00000011290; ENSORLG00000009003.
DR   eggNOG; ENOG410INDA; Eukaryota.
DR   eggNOG; ENOG410XSRH; LUCA.
DR   GeneTree; ENSGT00940000158426; -.
DR   InParanoid; H2LYS0; -.
DR   OMA; TAMGLEW; -.
DR   TreeFam; TF313537; -.
DR   Proteomes; UP000001038; Chromosome 19.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 4.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 4.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 4.
DR   SUPFAM; SSF82895; SSF82895; 4.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   1184       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017294057.
FT   DOMAIN      249    453       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1048   1086       PLAC. {ECO:0000259|PROSITE:PS50900}.
FT   REGION       54     91       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2LYS0}.
FT   REGION     1097   1184       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2LYS0}.
FT   COILED      227    247       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     54     74       Polar. {ECO:0000256|MobiDB-lite:H2LYS0}.
FT   COMPBIAS   1148   1162       Polar. {ECO:0000256|MobiDB-lite:H2LYS0}.
FT   COMPBIAS   1165   1184       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                H2LYS0}.
SQ   SEQUENCE   1184 AA;  132446 MW;  BEA0D2DFB76CBD03 CRC64;
     MNRFYLSIFL TWACECFSHF VPSEKVSGKL REYGLIVPFS TDSHGRYISH VVSAGSGSKS
     SDAASSLGSI SSSSRRRRRV ARGAPEMPSA TSPAAQHLFF NVTVFGKELH LRLKANRRLV
     APGAFVEWQE DFKEKSKEHI SGDCVFTGDV TDMPEASVAI SNCDGLAGLI RTDKGEFFIE
     PLEKGQQDVE SKGRVHVVYR RSAIKAGQQK SDFHNEDVGI ADLPAALDLV EHKLSESERK
     RRHAKKDDYN IEVLLAVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL GTNINIVLVR
     MIMVGYRQSI SLIERGNPSR SLEQVCRWAN TQQRHNPDHA EYHDHAIFLT RQDFGPAGMQ
     GYAPVTGMCH PLRSCTLNHE DGFSSAFVVA HETGHVLGME HDGQGNRCAD ETSMGSIMAP
     LVQAAFHRYH WSRCSKQELN RYIHSYDCLL DDPFEHKWPK LPELPGINYS MDEQCRFDFG
     VGYKMCTAFR TYDPCKQLWC SHPDNQYFCK TKKGPPVDGT DCAPGKWCFK GHCIWRSSQE
     PQGHDGSWSS WSKFGSCSRT CGGGIRSRSR QCNNPPPAYG GRDCPGSAFD YQMCNTEECA
     GAYEDFRAQQ CIQRSNKYHK NMKHTWLPYE DPDDSRKCEL SCISKETEEI VFMNQVVHDG
     TRCSYSDPYS VCARGECLHV GCDKEVGSYK EEDKCGVCEG DNSHCRTVKL TLTKTPKKNG
     MLKMFDIPIG ARHIVIEENE TSSHIIAVKN QVSGNFILNE KSEDAKLKTF IKNGLQWEYS
     SDGDRETLKT SGPLHDGIVV LVIPMEEEVK ISLTYKYIIH EDLLPLITNN NVLLSELDTY
     EWALKSWSQC SKPCGGGIQY TKYGCRRKSD GRLVHRNFCE SSKKPKPIRK RCNMLECSQP
     KWVMEDWSPC SKSCGKLGYQ TRVVQCMQAL HNGTSRPIHS KHCPTNRPET RRVCNHTACP
     AQWRTGAWSQ CSVSCGEGIQ QRQVVCKTSD NTVGECEGEK PETVLICKLS PCPGLPLSSP
     SSQMTENATM NGEAVYQMVP KNPVDKMSNE PCLGDKSIFC QMEVLARYCS IPGYYKLCCE
     SCSRKEGLPT NALDLHKPEV FPTQNPSKTA DAAARTSPPT DAALLQTPAD VSDREPPLPP
     GPPLPTADAS GGQNSTLSPD AVRSRRDNLG SERDSGHRTL SARK
//
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