ID H2LZL7_ORYLA Unreviewed; 717 AA.
AC H2LZL7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=LON peptidase N-terminal domain and ring finger 3 {ECO:0008006|Google:ProtNLM};
GN Name=lonrf3 {ECO:0000313|Ensembl:ENSORLP00000011589.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000011589.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000011589.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011589.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000011589.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000011589.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004073678.1; XM_004073630.2.
DR AlphaFoldDB; H2LZL7; -.
DR STRING; 8090.ENSORLP00000011589; -.
DR Ensembl; ENSORLT00000011590.2; ENSORLP00000011589.2; ENSORLG00000009245.2.
DR eggNOG; KOG1124; Eukaryota.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00440000033329; -.
DR InParanoid; H2LZL7; -.
DR OrthoDB; 3088759at2759; -.
DR TreeFam; TF327043; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000009245; Expressed in animal zygote and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16513; RING-HC_LONFs_rpt1; 1.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF41; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 3; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00028; TPR; 4.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 116..157
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 424..462
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 510..710
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT REGION 386..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 81596 MW; 71CD111949203B4C CRC64;
MGSERESMLH LAAQAFRAKN FDLAAEIYEC QLACLGEAES RLELMVKRAD ALAFGDKISD
AFEVYRQASE IEKLRPAHLA NLMDYLIRNI RTQDRRTAEQ EAARAVGESG RGLISCGMCL
GFLFEPVTLP CGHCFCRKCL EREKKEKERP VVCKECKASS RVADVQSYRV NVVLCNLLSK
WFPELQRAGR LRREGNGLYA ERRMEAALDK YNQAVLLAPT DHILFSNRSQ IHSSLKNFEK
ALRDAETACR LRPHWSRGHV RKAQALVSLG RTDEALREYL VSLSIEPDCK LAKTEALKLL
SNFLSPVTDQ VSERISDYSN SLSCRAHIKS CITTPFQTGI PAALSSESSF SCGLPGLEGS
EEVVRQPQTW RVDRCRLLKR KRRGSEEAEE RQEEADDQKK SKPEPAEGSI SLSVDVLDPT
DLECSLCMRL FYEPVTTPCG HTFCLQCLER CLDHNPKCPL CKEELSEYLV QRQYCKTVLM
ENLISKYLPS AFIERQKIHL EEMAELSNLN KNVPIFVCTM AFPTVPCPLH IFEPCYRLMI
RRCMETGTNC FGMCLGDDLK GFADYGCLLE IRDVKFFSDG RSVVDTIGRR RFKVIQHSER
DGYNTADIEY LEDVKVEGVE KRELQSLNDV VYELALVWVN SLKVEQKERI EGHFGPMPEK
DSELQANPNG PSWCWWLLAV LPLEGRAQLP FLALTSLKDR LSGIRKVLLF MAQNKHR
//
